DLL4

Delta-like protein 4. UniProt annotates extracellular residues 27–529.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected DLL4 RNA in the public colon adenocarcinoma cell groups.

Endothelial cells21.7%

Tumor cells2.7%

Adipocytes1.4%

Dendritic cells1.3%

Natural killer cells1.2%

B cells0.8%

Fibroblasts0.7%

CD4 T cells0.5%

Macrophages (group B)0.1%

CD8 T cells0.1%

Macrophages (group A)0.1%

Granulocytes0.0%

Regulatory T cells0.0%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 195. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000128917
UniProt accession: Q9NR61
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 685
Sequence SHA-256: c493b63e299b3245d088ff0cab36a90c477cd90b672953fe71ff07622e4e818e

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Canonical amino-acid sequence

MAAASRSASGWALLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPGCRTFFRVCLKHFQAVVSPGPCTFGTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIEAWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLAVLLVLLGMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKQQNHTLDYNLAPGPLGRGTMPGKFPHSDKSLGEKAPLRLHSEKPECRISAICSPRDSMYQSVCLISEERNECVIATEV

Sequence positions 1–685

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–26

Membrane-spanning segments

530–550 (Helical)

Source-annotated domains

27–529 (Extracellular); 551–685 (Cytoplasmic)

Source-annotated extracellular intervals

27–529

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
27	529	503	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 0bf0ba3e41d96b46a08ee82b867e21903cae1d1755ed0b5c61b12b1b91b001a9 Amino-acid sequence for this intervalSGVFQLQLQEFINERGVLASGRPCEPGCRTFFRVCLKHFQAVVSPGPCTFGTVSTPVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIEAWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVGLPPSFPW

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q9NR61

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
transmembrane: TRANSMEM 530..550; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 27..529; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 551..685; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..26; /evidence="ECO:0000269|PubMed:15340161"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Delta-like protein 4
Protein location: Transmembrane protein
Canonical sequence: Q9NR61 · 685 amino acids
Extracellular region: UniProt annotates extracellular residues 27–529.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in many
Protein specificity: Not detected
Protein distribution: Not detected
Immunohistochemistry reliability: Uncertain
Tissue cell-type enrichment: Adipose subcutaneous - Endothelial cells, Breast - Endothelial cells, Colon - Endothelial cells, Liver - Vascular endothelial cells, Prostate - Endothelial cells, Testis - Endothelial cells

Human Protein Atlas: DLL4

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

DLL4 · ENSG00000128917 · Q9NR61