ENG

Endoglin. UniProt annotates extracellular residues 26–586.

Predicted protein structure

A downloaded AlphaFold model connects the ENG sequence to its predicted three-dimensional structure.

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RNA expression by cell type

Percentage of cells with detected ENG RNA in the public colon adenocarcinoma cell groups.

Endothelial cells77.7%

Fibroblasts34.5%

Macrophages (group B)33.8%

Adipocytes14.6%

Macrophages (group A)12.4%

Dendritic cells3.3%

Tumor cells3.0%

Granulocytes2.9%

Natural killer cells2.6%

CD8 T cells2.4%

CD4 T cells2.2%

Regulatory T cells1.5%

B cells1.4%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 159. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000106991
UniProt accession: P17813
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 658
Sequence SHA-256: 9d83bcc4b07c00cde894c5077339d6e62f4ef394c3339ce76380957cc320da13

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Canonical amino-acid sequence

MDRGTLPLAVALLLASCSLSPTSLAETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRVLPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVASFVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKFVLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGLVLPAVLGITFGAFLIGALLTAALWYIYSHTRSPSKREPVVAVAAPASSESSSTNHSIGSTQSTPCSTSSMA

Sequence positions 1–658

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–25

Membrane-spanning segments

587–611 (Helical)

Source-annotated domains

26–586 (Extracellular); 612–658 (Cytoplasmic)

Source-annotated extracellular intervals

26–586

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
26	586	561	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 4e26520ec188e0b55ce5e09e8cc77b5551ec3fc672b8f8e5ac55e78484b0cda1 Amino-acid sequence for this intervalETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRVLPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVASFVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKFVLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKG

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P17813

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10545596, ECO:0000269|PubMed:1326540, ECO:0000269|PubMed:1692830, ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:8370410}; Single-pass type I membrane protein {ECO:0000305|PubMed:1692830, ECO:0000305|PubMed:8370410}.
transmembrane: TRANSMEM 587..611; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 26..586; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 612..658; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..25; /evidence="ECO:0000269|PubMed:1692830"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Endoglin
Protein location: Transmembrane protein
Canonical sequence: P17813 · 658 amino acids
Extracellular region: UniProt annotates extracellular residues 26–586.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in all
RNA tissue-specific nTPM: heart muscle: 518.6
Protein specificity: Tissue enhanced
Protein distribution: Detected in all
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: ovary: 10,331,372.8
Tissue cell-type enrichment: Adipose visceral - Endothelial cells, Breast - Endothelial cells, Colon - Endothelial cells, Heart muscle - Endothelial cells, Liver - Vascular endothelial cells, Minor Salivary Gland - Endothelial cells, Prostate - Endothelial cells, Stomach - Endothelial cells
Subcellular location: Plasma membrane

Human Protein Atlas: ENG

Structures

A predicted target model is available.

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Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

ENG · ENSG00000106991 · P17813