EPHB4

Ephrin type-B receptor 4. UniProt annotates extracellular residues 16–539.

Sequence and protein regions

Explore the EPHB4 sequence, select annotated regions, and copy a request to continue in Codex.

Open this view

RNA expression by cell type

Percentage of cells with detected EPHB4 RNA in the public colon adenocarcinoma cell groups.

Endothelial cells33.4%

Tumor cells9.2%

Fibroblasts4.0%

Adipocytes2.4%

Macrophages (group B)0.9%

Macrophages (group A)0.6%

B cells0.4%

CD8 T cells0.4%

Regulatory T cells0.3%

Granulocytes0.3%

CD4 T cells0.3%

Natural killer cells0.2%

Dendritic cells0.0%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 394. Source study · Measurements (JSON)

Sequence & binding sites

Choose a protein region, search amino-acid letters, or inspect a recorded binding site.

Loading sequence…

Open the sequence explorer

Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000196411
UniProt accession: P54760
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 987
Sequence SHA-256: 37003eca217f6b25fc4ae29a2d6ffc1e7b18df0a7f2e9f9ea509a636a68f8260

View and select the full canonical sequence

Canonical amino-acid sequence

MELRVLLCWASLAAALEETLLNTKLETADLKWVTFPQVDGQWEELSGLDEEQHSVRTYEVCDVQRAPGQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFYYESDADTATALTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNVKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCAQLTVNLTRFPETVPRELVVPVAGSCVVDAVPAPGPSPSLYCREDGQWAEQPVTGCSCAPGFEAAEGNTKCRACAQGTFKPLSGEGSCQPCPANSHSNTIGSAVCQCRVGYFRARTDPRGAPCTTPPSAPRSVVSRLNGSSLHLEWSAPLESGGREDLTYALRCRECRPGGSCAPCGGDLTFDPGPRDLVEPWVVVRGLRPDFTYTFEVTALNGVSSLATGPVPFEPVNVTTDREVPPAVSDIRVTRSSPSSLSLAWAVPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESEGWREQLALIAGTAVVGVVLVLVVIVVAVLCLRKQSNGREAEYSDKHGQYLIGHGTKVYIDPFTYEDPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVARENGGASHPLLDQRQPHYSAFGSVGEWLRAIKMGRYEESFAAAGFGSFELVSQISAEDLLRIGVTLAGHQKKILASVQHMKSQAKPGTPGGTGGPAPQY

Sequence positions 1–987

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–15

Membrane-spanning segments

540–560 (Helical)

Source-annotated domains

16–539 (Extracellular); 561–987 (Cytoplasmic)

Source-annotated extracellular intervals

16–539

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
16	539	524	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 b4540b5cbef8f4afe1f3cf0c0e075764ed99084437bebab332916612a0d6d508 Amino-acid sequence for this intervalLEETLLNTKLETADLKWVTFPQVDGQWEELSGLDEEQHSVRTYEVCDVQRAPGQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFYYESDADTATALTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNVKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCAQLTVNLTRFPETVPRELVVPVAGSCVVDAVPAPGPSPSLYCREDGQWAEQPVTGCSCAPGFEAAEGNTKCRACAQGTFKPLSGEGSCQPCPANSHSNTIGSAVCQCRVGYFRARTDPRGAPCTTPPSAPRSVVSRLNGSSLHLEWSAPLESGGREDLTYALRCRECRPGGSCAPCGGDLTFDPGPRDLVEPWVVVRGLRPDFTYTFEVTALNGVSSLATGPVPFEPVNVTTDREVPPAVSDIRVTRSSPSSLSLAWAVPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESEGWREQLA

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

Download source snapshot

Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P54760

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28687708, ECO:0000269|PubMed:8188704}; Single-pass type I membrane protein {ECO:0000269|PubMed:8188704}.
transmembrane: TRANSMEM 540..560; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 16..539; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 561..987; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..15; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Ephrin type-B receptor 4
Protein location: Transmembrane protein
Canonical sequence: P54760 · 987 amino acids
Extracellular region: UniProt annotates extracellular residues 16–539.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in many
Protein specificity: Low tissue specificity
Protein distribution: Detected in many
Immunohistochemistry reliability: Uncertain
Tissue cell-type enrichment: Adrenal gland - Adrenal cortex cells, Pituitary gland - Endothelial cells, Testis - Spermatogonia

Human Protein Atlas: EPHB4

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

EPHB4 · ENSG00000196411 · P54760