ERBB3

Receptor tyrosine-protein kinase erbB-3. UniProt annotates extracellular residues 20–643.

Predicted protein structure

A downloaded AlphaFold model connects the ERBB3 sequence to its predicted three-dimensional structure.

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RNA expression by cell type

Percentage of cells with detected ERBB3 RNA in the public colon adenocarcinoma cell groups.

Tumor cells32.7%

Adipocytes9.6%

Fibroblasts4.0%

Endothelial cells2.0%

Dendritic cells2.0%

Regulatory T cells1.8%

Macrophages (group B)1.7%

CD8 T cells1.3%

CD4 T cells1.3%

Granulocytes1.2%

Natural killer cells1.2%

B cells1.1%

Macrophages (group A)1.0%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 15. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000065361
UniProt accession: P21860
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 1342
Sequence SHA-256: 17edac2fa022b912a92821032c8b6d4a300cd07a4c81906cb7faa2b94996f600

View and select the full canonical sequence

Canonical amino-acid sequence

MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRT

Sequence positions 1–1342

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–19

Membrane-spanning segments

644–664 (Helical)

Source-annotated domains

20–643 (Extracellular); 665–1342 (Cytoplasmic)

Source-annotated extracellular intervals

20–643

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
20	643	624	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 0aa502f90c31b59610d29c2e3f30fae4cbd8df6bdcabddf6ced9d0278f630a2f Amino-acid sequence for this intervalSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNGRSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTSCVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEERLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPIYKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLT

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P21860

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subcellular_location: SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:33497358}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
transmembrane: TRANSMEM 644..664; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 20..643; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 665..1342; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..19; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Receptor tyrosine-protein kinase erbB-3
Protein location: Transmembrane protein
Canonical sequence: P21860 · 1,342 amino acids
Extracellular region: UniProt annotates extracellular residues 20–643.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in many
Protein specificity: Tissue enriched
Protein distribution: Detected in single
Immunohistochemistry reliability: Approved
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: lung: 46,964.9
Tissue cell-type enrichment: Adipose subcutaneous - Smooth muscle cells, Adipose visceral - Mesothelial cells, Adrenal gland - Adrenal medulla cells, Breast - Breast glandular cells, Colon - Enteric glia cells, Lung - Alveolar cells type 2, Minor Salivary Gland - Minor salivary glandular cells, Skin - Keratinocyte (granular), Testis - Spermatocytes
Subcellular location: Plasma membrane

Human Protein Atlas: ERBB3

Structures

A predicted target model is available.

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Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

ERBB3 · ENSG00000065361 · P21860