FGFR1

Fibroblast growth factor receptor 1. UniProt annotates extracellular residues 22–376.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected FGFR1 RNA in the public colon adenocarcinoma cell groups.

Fibroblasts47.2%

Endothelial cells24.8%

Adipocytes21.8%

Macrophages (group B)5.2%

Regulatory T cells4.2%

Granulocytes1.9%

Macrophages (group A)1.9%

CD4 T cells1.9%

Natural killer cells1.7%

Tumor cells1.0%

CD8 T cells0.9%

B cells0.9%

Dendritic cells0.0%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 11. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000077782
UniProt accession: P11362
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 822
Sequence SHA-256: ef0ddbb0badae4eac53608fa57cf54c55cb837d4929048fa6a2339bb30ae8f03

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Canonical amino-acid sequence

MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR

Sequence positions 1–822

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–21

Membrane-spanning segments

377–397 (Helical)

Source-annotated domains

22–376 (Extracellular); 398–822 (Cytoplasmic)

Source-annotated extracellular intervals

22–376

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
22	376	355	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 c9d91a83e9f8be5ecfc3d001e2597e535620cdacc47c8f20d4c1cfd0c72e86b1 Amino-acid sequence for this intervalRPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLE

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P11362

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.
transmembrane: TRANSMEM 377..397; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 22..376; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 398..822; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..21
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Fibroblast growth factor receptor 1
Protein location: Transmembrane protein
Canonical sequence: P11362 · 822 amino acids
Extracellular region: UniProt annotates extracellular residues 22–376.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in all
Protein specificity: Group enriched
Protein distribution: Detected in many
Immunohistochemistry reliability: Approved
Immunofluorescence reliability: Approved
Protein tissue-specific intensity: intestine: 172,623.7; ovary: 284,828.1
Tissue cell-type enrichment: Breast - Fibroblasts, Kidney - Endothelial cells
Subcellular location: Microtubules, Cytokinetic bridge, Mitotic spindle

Human Protein Atlas: FGFR1

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

FGFR1 · ENSG00000077782 · P11362