HAVCR2

Hepatitis A virus cellular receptor 2. UniProt annotates extracellular residues 22–202.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected HAVCR2 RNA in the public colon adenocarcinoma cell groups.

Macrophages (group B)34.5%

Natural killer cells27.1%

Macrophages (group A)20.8%

CD8 T cells14.5%

Granulocytes13.5%

Regulatory T cells13.0%

Dendritic cells11.1%

CD4 T cells3.7%

Endothelial cells0.8%

B cells0.7%

Adipocytes0.5%

Fibroblasts0.4%

Tumor cells0.3%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 232. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000135077
UniProt accession: Q8TDQ0
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 301
Sequence SHA-256: 19fad6122957287e994f5b674a6ed813fad5c4be3a60f4403e005ed2dbed0ffa

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Canonical amino-acid sequence

MFSHLPFDCVLLLLLLLLTRSSEVEYRAEVGQNAYLPCFYTPAAPGNLVPVCWGKGACPVFECGNVVLRTDERDVNYWTSRYWLNGDFRKGDVSLTIENVTLADSGIYCCRIQIPGIMNDEKFNLKLVIKPAKVTPAPTRQRDFTAAFPRMLTTRGHGPAETQTLGSLPDINLTQISTLANELRDSRLANDLRDSGATIRIGIYIGAGICAGLALALIFGALIFKWYSHSKEKIQNLSLISLANLPPSGLANAVAEGIRSEENIYTIEENVYEVEEPNEYYCYVSSRQQPSQPLGCRFAMP

Sequence positions 1–301

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–21

Membrane-spanning segments

203–223 (Helical)

Source-annotated domains

22–202 (Extracellular); 224–301 (Cytoplasmic)

Lipid attachment sites

296–296 (S-palmitoyl cysteine)

Source-annotated extracellular intervals

22–202

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
22	202	181	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 c3152b9d90f174c1516043b17760fd54e2135963a30afc8f17b10a5c28f0c188 Amino-acid sequence for this intervalSEVEYRAEVGQNAYLPCFYTPAAPGNLVPVCWGKGACPVFECGNVVLRTDERDVNYWTSRYWLNGDFRKGDVSLTIENVTLADSGIYCCRIQIPGIMNDEKFNLKLVIKPAKVTPAPTRQRDFTAAFPRMLTTRGHGPAETQTLGSLPDINLTQISTLANELRDSRLANDLRDSGATIRIG

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q8TDQ0

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:39546589}; Single-pass type I membrane protein {ECO:0000305}. Cell junction {ECO:0000269|PubMed:24337741}. Cell membrane {ECO:0000269|PubMed:30374066}. Note=Localizes to the immunological synapse between CD8+ T-cells and target cells. {ECO:0000269|PubMed:24337741}.
transmembrane: TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 22..202; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 224..301; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..21; /evidence="ECO:0000255"
lipidation: LIPID 296; /note="S-palmitoyl cysteine"; /evidence="ECO:0000269|PubMed:39546589"

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Hepatitis A virus cellular receptor 2
Protein location: Transmembrane protein
Canonical sequence: Q8TDQ0 · 301 amino acids
Extracellular region: UniProt annotates extracellular residues 22–202.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in all
Protein specificity: Tissue enriched
Protein distribution: Detected in single
Immunohistochemistry reliability: Enhanced
Protein tissue-specific intensity: lymphoid tissue: 343,181.6
Tissue cell-type enrichment: Adipose subcutaneous - Macrophages, Adipose visceral - Macrophages, Adrenal gland - Macrophages, Breast - Macrophages, Colon - Macrophages, Heart muscle - Macrophages, Kidney - Proximal tubular cells, Minor Salivary Gland - Macrophages, Pituitary gland - Macrophages, Prostate - Macrophages, Skeletal muscle - Macrophages, Stomach - Macrophages

Human Protein Atlas: HAVCR2

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

HAVCR2 · ENSG00000135077 · Q8TDQ0