HLA-B

HLA class I histocompatibility antigen, B alpha chain. UniProt annotates extracellular residues 25–309.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected HLA-B RNA in the public colon adenocarcinoma cell groups.

Regulatory T cells95.1%

CD8 T cells93.7%

CD4 T cells93.2%

Endothelial cells93.1%

Dendritic cells92.2%

Natural killer cells89.5%

B cells87.9%

Macrophages (group B)87.2%

Macrophages (group A)83.5%

Fibroblasts82.8%

Granulocytes68.3%

Tumor cells65.2%

Adipocytes63.0%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 56. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000234745
UniProt accession: P01889
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 362
Sequence SHA-256: 5de81f208e7148a6c5163dc26042423d3e3fdd21b2eb3c95625b3a80f58583fb

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Canonical amino-acid sequence

MLVMAPRTVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQSMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPSSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSLTA

Sequence positions 1–362

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–24

Membrane-spanning segments

310–333 (Helical)

Source-annotated domains

25–309 (Extracellular); 334–362 (Cytoplasmic)

Source-annotated extracellular intervals

25–309

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
25	309	285	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 b6310ea0990dc128268c31edc87005ea3822adc0baf53c0d4cd4504272567108 Amino-acid sequence for this intervalGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQSMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPSSQSTVPIV

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P01889

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25480565, ECO:0000269|PubMed:26439010, ECO:0000269|PubMed:9620674}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:9620674}; Single-pass type I membrane protein {ECO:0000255}.
transmembrane: TRANSMEM 310..333; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 25..309; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 334..362; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..24; /evidence="ECO:0000269|PubMed:518865"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: HLA class I histocompatibility antigen, B alpha chain
Protein location: Transmembrane protein
Canonical sequence: P01889 · 362 amino acids
Extracellular region: UniProt annotates extracellular residues 25–309.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: lymphoid tissue: 2,350.0
Protein specificity: Tissue enhanced
Protein distribution: Detected in all
Immunohistochemistry reliability: Enhanced
Protein tissue-specific intensity: lymphoid tissue: 152,683,958.1
Tissue cell-type enrichment: Skin - Keratinocyte (other), Thyroid gland - T-cells

Human Protein Atlas: HLA-B

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

HLA-B · ENSG00000234745 · P01889