HLA-E

HLA class I histocompatibility antigen, alpha chain E. UniProt annotates extracellular residues 22–305.

Sequence and protein regions

Explore the HLA-E sequence, select annotated regions, and copy a request to continue in Codex.

Open this view

RNA expression by cell type

Percentage of cells with detected HLA-E RNA in the public colon adenocarcinoma cell groups.

Endothelial cells87.4%

Regulatory T cells83.2%

CD4 T cells81.1%

CD8 T cells80.1%

B cells78.1%

Dendritic cells75.2%

Macrophages (group B)73.0%

Natural killer cells72.7%

Macrophages (group A)66.1%

Fibroblasts65.6%

Granulocytes53.9%

Adipocytes46.0%

Tumor cells42.1%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 658. Source study · Measurements (JSON)

Sequence & binding sites

Choose a protein region, search amino-acid letters, or inspect a recorded binding site.

Loading sequence…

Open the sequence explorer

Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000204592
UniProt accession: P13747
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 358
Sequence SHA-256: c44ad4cd8d5338b0dfd0c9e1bf242e7a650b209b7af90aaf304e9f8a95f43903

View and select the full canonical sequence

Canonical amino-acid sequence

MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMHGCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQPTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHSL

Sequence positions 1–358

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–21

Membrane-spanning segments

306–329 (Helical)

Source-annotated domains

22–305 (Extracellular); 330–358 (Cytoplasmic)

Source-annotated extracellular intervals

22–305

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
22	305	284	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 49f4fb74df4268904bc5badaaffb8adb7e05d8f7321411db6eb17be9fabfc3e5 Amino-acid sequence for this intervalGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMHGCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQPTIPI

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

Download source snapshot

Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P13747

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17179229, ECO:0000269|PubMed:37264229, ECO:0000269|PubMed:9427624}; Single-pass type I membrane protein. Golgi apparatus membrane {ECO:0000269|PubMed:17179229}.; SUBCELLULAR LOCATION: [Soluble HLA class I histocompatibility antigen, alpha chain E]: Secreted {ECO:0000269|PubMed:17179229}.
transmembrane: TRANSMEM 306..329; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 22..305; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 330..358; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..21; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: HLA class I histocompatibility antigen, alpha chain E
Protein location: Transmembrane protein
Canonical sequence: P13747 · 358 amino acids
Extracellular region: UniProt annotates extracellular residues 22–305.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in many
Protein specificity: Tissue enhanced
Protein distribution: Detected in many
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: lymphoid tissue: 19,305,177.4
Tissue cell-type enrichment: Adipose subcutaneous - Endothelial cells, Breast - Endothelial cells, Colon - Endothelial cells, Kidney - Endothelial cells, Pituitary gland - Endothelial cells, Skeletal muscle - Endothelial cells, Testis - Endothelial cells
Subcellular location: Vesicles, Plasma membrane

Human Protein Atlas: HLA-E

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

HLA-E · ENSG00000204592 · P13747