JAG1

Protein jagged-1. UniProt annotates extracellular residues 34–1067.

Sequence and protein regions

Explore the JAG1 sequence, select annotated regions, and copy a request to continue in Codex.

Open this view

RNA expression by cell type

Percentage of cells with detected JAG1 RNA in the public colon adenocarcinoma cell groups.

Endothelial cells32.8%

Fibroblasts21.5%

Adipocytes16.4%

Tumor cells10.8%

Dendritic cells3.9%

Macrophages (group B)3.3%

Macrophages (group A)3.0%

Natural killer cells1.7%

Granulocytes1.2%

CD4 T cells0.8%

Regulatory T cells0.7%

B cells0.7%

CD8 T cells0.6%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 222. Source study · Measurements (JSON)

Sequence & binding sites

Choose a protein region, search amino-acid letters, or inspect a recorded binding site.

Loading sequence…

Open the sequence explorer

Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000101384
UniProt accession: P78504
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 1218
Sequence SHA-256: 9e09344716f80e5ff5d1f913ca90061a26fdaaf4f8836649f84bd66c1dbd4aa5

View and select the full canonical sequence

Canonical amino-acid sequence

MRSPRTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARNPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRIVLPFSFAWPRSYTLLVEAWDSSNDTVQPDSIIEKASHSGMINPSRQWQTLKQNTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQDNCANITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYSIYIACEPSPSANNEIHVAISAEDIRDDGNPIKEITDKIIDLVSKRDGNSSLIAAVAEVRVQRRPLKNRTDFLVPLLSSVLTVAWICCLVTAFYWCLRKRRKPGSHTHSASEDNTTNNVREQLNQIKNPIEKHGANTVPIKDYENKNSKMSKIRTHNSEVEEDDMDKHQQKARFAKQPAYTLVDREEKPPNGTPTKHPNWTNKQDNRDLESAQSLNRMEYIV

Sequence positions 1–1218

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–33

Membrane-spanning segments

1068–1093 (Helical)

Source-annotated domains

34–1067 (Extracellular); 1094–1218 (Cytoplasmic)

Source-annotated extracellular intervals

34–1067

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
34	1067	1034	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 2a213c1a4cd375d59352e9b0a9396ecb71c3cce0cf7b23d66c8a4526aec691ca Amino-acid sequence for this intervalQFELEILSMQNVNGELQNGNCCGGARNPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRIVLPFSFAWPRSYTLLVEAWDSSNDTVQPDSIIEKASHSGMINPSRQWQTLKQNTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKCTSDSYYQDNCANITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYSIYIACEPSPSANNEIHVAISAEDIRDDGNPIKEITDKIIDLVSKRDGNSSLIAAVAEVRVQRRPLKNRTD

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

Download source snapshot

Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P78504

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000269|PubMed:32065591}.
transmembrane: TRANSMEM 1068..1093; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 34..1067; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 1094..1218; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..33; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Protein jagged-1
Protein location: Transmembrane protein
Canonical sequence: P78504 · 1,218 amino acids
Extracellular region: UniProt annotates extracellular residues 34–1067.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in all
Protein specificity: Group enriched
Protein distribution: Detected in some
Immunohistochemistry reliability: Supported
Immunofluorescence reliability: Approved
Protein tissue-specific intensity: intestine: 82,624.3; lung: 60,805.6; ovary: 176,221.1
Tissue cell-type enrichment: Breast - Endothelial cells, Kidney - Fibroblasts, Spleen - Endothelial cells
Subcellular location: Golgi apparatus, Plasma membrane

Human Protein Atlas: JAG1

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

JAG1 · ENSG00000101384 · P78504