KIT

Mast/stem cell growth factor receptor Kit. UniProt annotates extracellular residues 26–524.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected KIT RNA in the public colon adenocarcinoma cell groups.

Granulocytes65.6%

Macrophages (group A)5.5%

Endothelial cells3.6%

Natural killer cells1.4%

Tumor cells1.1%

CD4 T cells0.8%

Dendritic cells0.7%

Fibroblasts0.6%

Macrophages (group B)0.4%

Adipocytes0.4%

CD8 T cells0.2%

Regulatory T cells0.2%

B cells0.2%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 9. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000157404
UniProt accession: P10721
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 976
Sequence SHA-256: 7b430dd4888d7410e8d65d331b8bd4f5bd9abd4f3a9290f2a93f37b0ed495c5c

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Canonical amino-acid sequence

MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSVGSTASSSQPLLVHDDV

Sequence positions 1–976

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–25

Membrane-spanning segments

525–545 (Helical)

Source-annotated domains

26–524 (Extracellular); 546–976 (Cytoplasmic)

Source-annotated extracellular intervals

26–524

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
26	524	499	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 cfc07b823706a7923de7db431c8280828f76dabc8eaf05cd06a6bfeabee73eec Amino-acid sequence for this intervalQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTP

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P10721

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subcellular_location: SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:20601678}. Note=Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head. {ECO:0000269|PubMed:20601678}.
transmembrane: TRANSMEM 525..545; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 26..524; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 546..976; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..25; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Mast/stem cell growth factor receptor Kit
Protein location: Transmembrane protein
Canonical sequence: P10721 · 976 amino acids
Extracellular region: UniProt annotates extracellular residues 26–524.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: breast: 79.2
Protein specificity: Tissue enriched
Protein distribution: Detected in some
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: cerebral cortex: 2,247,494.4
Tissue cell-type enrichment: Adipose subcutaneous - Mast cells, Lung - Mast cells, Testis - Spermatogonia, Thyroid gland - Thyroid glandular cells
Subcellular location: Plasma membrane

Human Protein Atlas: KIT

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

KIT · ENSG00000157404 · P10721