LIMA1

LIM domain and actin-binding protein 1. The canonical sequence contains 759 amino acids.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected LIMA1 RNA in the public colon adenocarcinoma cell groups.

Fibroblasts54.3%

Endothelial cells46.9%

Tumor cells32.8%

Adipocytes29.5%

Regulatory T cells18.8%

Macrophages (group B)14.4%

Dendritic cells9.8%

CD8 T cells7.8%

CD4 T cells7.4%

Macrophages (group A)6.0%

Natural killer cells5.2%

B cells4.5%

Granulocytes2.2%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 839. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000050405
UniProt accession: Q9UHB6
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 759
Sequence SHA-256: d09ccefe7c2bfdced1a34d5b22166e6c404cde3a727eb657af6f0552c68bdaf5

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Canonical amino-acid sequence

MESSPFNRRQWTSLSLRVTAKELSLVNKNKSSAIVEIFSKYQKAAEETNMEKKRSNTENLSQHFRKGTLTVLKKKWENPGLGAESHTDSLRNSSTEIRHRADHPPAEVTSHAASGAKADQEEQIHPRSRLRSPPEALVQGRYPHIKDGEDLKDHSTESKKMENCLGESRHEVEKSEISENTDASGKIEKYNVPLNRLKMMFEKGEPTQTKILRAQSRSASGRKISENSYSLDDLEIGPGQLSSSTFDSEKNESRRNLELPRLSETSIKDRMAKYQAAVSKQSSSTNYTNELKASGGEIKIHKMEQKENVPPGPEVCITHQEGEKISANENSLAVRSTPAEDDSRDSQVKSEVQQPVHPKPLSPDSRASSLSESSPPKAMKKFQAPARETCVECQKTVYPMERLLANQQVFHISCFRCSYCNNKLSLGTYASLHGRIYCKPHFNQLFKSKGNYDEGFGHRPHKDLWASKNENEEILERPAQLANARETPHSPGVEDAPIAKVGVLAASMEAKASSQQEKEDKPAETKKLRIAWPPPTELGSSGSALEEGIKMSKPKWPPEDEISKPEVPEDVDLDLKKLRRSSSLKERSRPFTVAASFQSTSVKSPKTVSPPIRKGWSMSEQSEESVGGRVAERKQVENAKASKKNGNVGKTTWQNKESKGETGKRSKEGHSLEMENENLVENGADSDEDDNSFLKQQSPQEPKSLNWSSFVDNTFAEEFTTQNQKSQDVELWEGEVVKELSVEEQIKRNRYYDEDEDEE

This collection has no explicit extracellular interval for this protein.

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q9UHB6

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subcellular_location: SUBCELLULAR LOCATION: Cytoplasm. Cell junction, focal adhesion {ECO:0000269|PubMed:10618726, ECO:0000269|PubMed:24694988}. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:10618726}. Cell membrane {ECO:0000250|UniProtKB:Q9ERG0}. Cell projection, ruffle {ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. Cell projection, lamellipodium {ECO:0000269|PubMed:33999101}. Note=Expressed in the brush border membrane of the small intestine and colocalizes with NPC1L1 and MYO5B (PubMed:29880681). Colocalizes with PXN at focal adhesions in mesangial cells (PubMed:24694988). Colocalizes with actin stress fibers in quiescent cells. PDGF stimulation induced disassembly of stress fibers and formation of peripheral and dorsal ruffles, where LIMA1 is relocalized (By similarity). Localized at the lamellipodia, just behind lamellipodia actin ruffles (PubMed:33999101). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:24694988, ECO:0000269|PubMed:29880681, ECO:0000269|PubMed:33999101}.
transmembrane: Not recorded
topological_domain: Not recorded
signal_peptide: Not recorded
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: LIM domain and actin-binding protein 1
Protein location: Cytoplasm, cytoskeleton and cell junctions
Canonical sequence: Q9UHB6 · 759 amino acids

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in all
Protein specificity: Low tissue specificity
Protein distribution: Detected in all
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Approved
Tissue cell-type enrichment: Skeletal muscle - Fibroblasts, Thyroid gland - Fibroblasts
Subcellular location: Plasma membrane, Actin filaments

Human Protein Atlas: LIMA1

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

LIMA1 · ENSG00000050405 · Q9UHB6