Surface AtlasMET
Hepatocyte growth factor receptor. UniProt annotates extracellular residues 25–932.
Published binding interface
Structure 4K3J records MET in contact with HGF. Select the contact residues to inspect this interface.
Open this viewRNA expression by cell type
Percentage of cells with detected MET RNA in the public colon adenocarcinoma cell groups.
Tumor cells14.8%
Endothelial cells10.8%
Dendritic cells1.3%
Macrophages (group B)1.2%
Adipocytes1.2%
Fibroblasts0.9%
Macrophages (group A)0.5%
CD4 T cells0.5%
B cells0.4%
CD8 T cells0.3%
Regulatory T cells0.3%
Granulocytes0.2%
Natural killer cells0.0%
Inspect the molecular structure
Published reference structure
MET with HGF and onartuzumab
- PDB entry
- 4K3J
- Target ID
- T-ENSG00000105976
- HGF · chain A (ribbon)
- MET ectodomain · chain B (ribbon)
- onartuzumab Fab heavy chain · chain H (ribbon)
- onartuzumab Fab light chain · chain L (ribbon)
Sequence & binding sites
Choose a protein region, search amino-acid letters, or inspect a recorded binding site.
Loading sequence…
Open the sequence explorerSequence annotations and source records
Canonical sequence and topology
- Target ID
- T-ENSG00000105976
- UniProt accession
- P08581
- Sequence state
- available
- Canonical sequence
- Yes
- Length in amino acids
- 1390
- Sequence SHA-256
- cc24e8701a5717fd1fa418174adb3b6cbaeae8a76f78b33a995f44c5bb394056
View and select the full canonical sequence
Gray shows the full canonical sequence. Colored spans mark the listed intervals.
Signal peptide
1–24
Membrane-spanning segments
933–955 (Helical)
Source-annotated domains
25–932 (Extracellular); 956–1390 (Cytoplasmic)
Source-annotated extracellular intervals
25–932
UniProt annotates the following extracellular intervals.
| Start | End | Length | Sequence and source |
|---|---|---|---|
| 25 | 932 | 908 | Sequence and source
|
Sequence and topology sources
- Source role
- canonical-sequence
- Source
- alphafold-db-canonical-uniprot-field
- Extracted field
- uniprotSequence
- Source row accession
- Not recorded
- Source role
- reviewed-topology
- Source
- UniProt reviewed human surface-field snapshot
- Extracted field
- Not recorded
- Source row accession
- P08581
Download source snapshot (gzip)
- subcellular_location
- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
- transmembrane
- TRANSMEM 933..955; /note="Helical"; /evidence="ECO:0000255"
- topological_domain
- TOPO_DOM 25..932; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 956..1390; /note="Cytoplasmic"; /evidence="ECO:0000255"
- signal_peptide
- SIGNAL 1..24; /evidence="ECO:0000255"
- lipidation
- Not recorded
Protein identity and location
- Protein
- Hepatocyte growth factor receptor
- Protein location
- Transmembrane protein
- Canonical sequence
- P08581 · 1,390 amino acids
- Extracellular region
- UniProt annotates extracellular residues 25–932.
More structures and generated models
Structure snapshots
Expression in normal tissues
- RNA specificity
- Tissue enhanced
- RNA distribution
- Detected in many
- RNA tissue-specific nTPM
- liver: 40.1
- Protein specificity
- Group enriched
- Protein distribution
- Detected in some
- Immunohistochemistry reliability
- Approved
- Immunofluorescence reliability
- Approved
- Protein tissue-specific intensity
- intestine: 104,706.0; liver: 110,974.2
- Tissue cell-type enrichment
- Adipose visceral - Mesothelial cells, Lung - Alveolar cells type 2, Testis - Endothelial cells
- Subcellular location
- Plasma membrane
Structures
| Name | Stable ID | Action | Format | Status | Claim |
|---|---|---|---|---|---|
| 4K3J | S-RCSB-4K3J | Not recorded | Not recorded | not recorded | verified deposited experimental structure |
Sources and downloads
MET · ENSG00000105976 · P08581