NRP1

Neuropilin-1. UniProt annotates extracellular residues 22–856.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected NRP1 RNA in the public colon adenocarcinoma cell groups.

Endothelial cells49.9%

Macrophages (group B)42.1%

Fibroblasts25.1%

Adipocytes17.8%

Dendritic cells13.1%

Macrophages (group A)7.1%

Tumor cells2.5%

Granulocytes1.5%

Regulatory T cells0.6%

CD4 T cells0.4%

CD8 T cells0.4%

B cells0.3%

Natural killer cells0.2%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 208. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000099250
UniProt accession: O14786
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 923
Sequence SHA-256: 1d2551ade453a33a915755fda9144bb4924af48001cae8fe701fa2663318092c

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Canonical amino-acid sequence

MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNTQSTYSEA

Sequence positions 1–923

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–21

Membrane-spanning segments

857–879 (Helical)

Source-annotated domains

22–856 (Extracellular); 880–923 (Cytoplasmic)

Source-annotated extracellular intervals

22–856

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
22	856	835	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 69ad0040abcdea3cda3ce57e5f1b2b38065bc5f1c44c6b06f25cf2a5127eb18a Amino-acid sequence for this intervalFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDP

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: O14786

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subcellular_location: SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:10688880}.; SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305|PubMed:30623799}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:30623799}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:30623799}.; SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34742300}. Note=(Microbial infection) Proteolytically cleaved at the cell membrane upon H.pylori infection. {ECO:0000269|PubMed:34742300}.
transmembrane: TRANSMEM 857..879; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 22..856; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 880..923; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..21; /evidence="ECO:0000269|PubMed:10688880, ECO:0000269|PubMed:9529250"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Neuropilin-1
Protein location: Transmembrane protein
Canonical sequence: O14786 · 923 amino acids
Extracellular region: UniProt annotates extracellular residues 22–856.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in all
Protein specificity: Group enriched
Protein distribution: Detected in all
Immunohistochemistry reliability: Approved
Immunofluorescence reliability: Uncertain
Protein tissue-specific intensity: heart muscle: 3,475,461.4; skeletal muscle: 13,871,393.6
Tissue cell-type enrichment: Adipose subcutaneous - Endothelial cells, Adipose visceral - Endothelial cells, Adrenal gland - Fibroblasts, Breast - Endothelial cells, Prostate - Endothelial cells, Skeletal muscle - Fibroblasts
Subcellular location: Mitochondria

Human Protein Atlas: NRP1

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

NRP1 · ENSG00000099250 · O14786