OGT

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit. The canonical sequence contains 1,046 amino acids.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected OGT RNA in the public colon adenocarcinoma cell groups.

Dendritic cells22.9%

B cells18.2%

Endothelial cells17.8%

Tumor cells16.7%

Fibroblasts14.6%

Regulatory T cells13.3%

CD4 T cells12.0%

CD8 T cells11.4%

Natural killer cells10.2%

Macrophages (group B)9.6%

Macrophages (group A)8.5%

Adipocytes8.5%

Granulocytes6.0%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 110. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000147162
UniProt accession: O15294
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 1046
Sequence SHA-256: b606c098eae182300f53c1c144db0b2dcc69e268edb382758e324acb4ebe6ea2

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Canonical amino-acid sequence

MASSVGNVADSTEPTKRMLSFQGLAELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSNTALNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIKPVEVTESA

This collection has no explicit extracellular interval for this protein.

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: O15294

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subcellular_location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:27713473}. Cytoplasm {ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:27713473}. Note=Predominantly localizes to the nucleus (PubMed:26678539). Translocates into the nucleus via association with importin KPNA1 (PubMed:27713473). {ECO:0000269|PubMed:26678539, ECO:0000269|PubMed:27713473}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion {ECO:0000269|PubMed:20824293}. Membrane {ECO:0000269|PubMed:20824293}. Note=Associates with the mitochondrial inner membrane. {ECO:0000269|PubMed:20824293}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:21285374}. Nucleus {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21285374}. Cell membrane {ECO:0000250|UniProtKB:P56558}. Mitochondrion membrane {ECO:0000250|UniProtKB:P56558}. Cell projection {ECO:0000250|UniProtKB:P56558}. Note=Mostly in the nucleus. Retained in the nucleus via interaction with HCFC1 (PubMed:21285374). After insulin induction, translocated from the nucleus to the cell membrane via phosphatidylinositide binding. Colocalizes with AKT1 at the plasma membrane. TRAK1 recruits this protein to mitochondria. In the absence of TRAK1, localizes in cytosol and nucleus (By similarity). {ECO:0000250|UniProtKB:P56558, ECO:0000269|PubMed:21285374}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000303|PubMed:31527085}. Nucleus {ECO:0000303|PubMed:31527085}.
transmembrane: Not recorded
topological_domain: Not recorded
signal_peptide: Not recorded
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Protein location: Nucleus and cytoplasm
Canonical sequence: O15294 · 1,046 amino acids

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in all
Protein specificity: Tissue enriched
Protein distribution: Detected in many
Immunohistochemistry reliability: Approved
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: cerebral cortex: 44,017,520.6
Subcellular location: Nucleoplasm

Human Protein Atlas: OGT

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

OGT · ENSG00000147162 · O15294