PDGFRA

Platelet-derived growth factor receptor alpha. UniProt annotates extracellular residues 24–528.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected PDGFRA RNA in the public colon adenocarcinoma cell groups.

Fibroblasts49.1%

Adipocytes21.4%

Dendritic cells4.6%

Macrophages (group B)1.4%

Endothelial cells1.1%

Tumor cells0.8%

Macrophages (group A)0.8%

B cells0.7%

CD4 T cells0.4%

Granulocytes0.3%

Natural killer cells0.2%

CD8 T cells0.2%

Regulatory T cells0.1%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 10. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000134853
UniProt accession: P16234
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 1089
Sequence SHA-256: 96a4d83a02900a0cba9954d64106f1a532b0209e0d2b86d205a98bd847335682

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Canonical amino-acid sequence

MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDSSDLVEDSFL

Sequence positions 1–1089

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–23

Membrane-spanning segments

529–549 (Helical)

Source-annotated domains

24–528 (Extracellular); 550–1089 (Cytoplasmic)

Source-annotated extracellular intervals

24–528

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
24	528	505	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 9ed7f53bf8553c7aef6059edbfe497e84c0fb0553684c3f813740fe64cf77d1d Amino-acid sequence for this intervalQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVA

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P16234

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14644164, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664}; Single-pass type I membrane protein {ECO:0000269|PubMed:14644164, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664}. Cell projection, cilium {ECO:0000250|UniProtKB:P26618}. Golgi apparatus {ECO:0000250|UniProtKB:P26618}.
transmembrane: TRANSMEM 529..549; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 24..528; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 550..1089; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..23
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Platelet-derived growth factor receptor alpha
Protein location: Transmembrane protein
Canonical sequence: P16234 · 1,089 amino acids
Extracellular region: UniProt annotates extracellular residues 24–528.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in all
RNA tissue-specific nTPM: ovary: 188.3
Protein specificity: Tissue enriched
Protein distribution: Detected in many
Immunohistochemistry reliability: Supported
Immunofluorescence reliability: Approved
Protein tissue-specific intensity: ovary: 6,193,217.7
Tissue cell-type enrichment: Adrenal gland - Fibroblasts, Breast - Fibroblasts, Heart muscle - Fibroblasts, Kidney - Fibroblasts, Minor Salivary Gland - Macrophages, Pituitary gland - Fibroblasts, Prostate - Fibroblasts, Spleen - Fibroblasts_2
Subcellular location: Nucleoplasm, Plasma membrane, Cell Junctions

Human Protein Atlas: PDGFRA

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

PDGFRA · ENSG00000134853 · P16234