PDGFRB

Platelet-derived growth factor receptor beta. UniProt annotates extracellular residues 33–532.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected PDGFRB RNA in the public colon adenocarcinoma cell groups.

Fibroblasts44.1%

Adipocytes23.3%

Natural killer cells2.6%

Endothelial cells2.1%

CD8 T cells1.2%

Macrophages (group A)1.1%

Tumor cells1.1%

Macrophages (group B)1.0%

Granulocytes0.7%

Dendritic cells0.7%

CD4 T cells0.6%

Regulatory T cells0.5%

B cells0.3%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 40. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000113721
UniProt accession: P09619
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 1106
Sequence SHA-256: 809c105e2a6e885c842e5d098845d69476d417336b2a21c12259fdcbc240cb32

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Canonical amino-acid sequence

MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILALVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDNDYIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQVEPEPELEQLPDSGCPAPRAEAEDSFL

Sequence positions 1–1106

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–32

Membrane-spanning segments

533–553 (Helical)

Source-annotated domains

33–532 (Extracellular); 554–1106 (Cytoplasmic)

Source-annotated extracellular intervals

33–532

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
33	532	500	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 a2e0a61002f9df7cfb6d89a5cc53f6261168fbe328875459e858490de6163194 Amino-acid sequence for this intervalLVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKV

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P09619

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.
transmembrane: TRANSMEM 533..553; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 33..532; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 554..1106; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..32; /evidence="ECO:0000269|PubMed:15340161"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Platelet-derived growth factor receptor beta
Protein location: Transmembrane protein
Canonical sequence: P09619 · 1,106 amino acids
Extracellular region: UniProt annotates extracellular residues 33–532.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in many
Protein specificity: Low tissue specificity
Protein distribution: Detected in all
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Supported
Tissue cell-type enrichment: Adipose subcutaneous - Adipose progenitor cells, Adipose visceral - Adipose progenitor cells, Adrenal gland - Fibroblasts, Prostate - Fibroblasts, Skeletal muscle - Endothelial cells
Subcellular location: Vesicles

Human Protein Atlas: PDGFRB

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

PDGFRB · ENSG00000113721 · P09619