PECAM1

Platelet endothelial cell adhesion molecule. UniProt annotates extracellular residues 28–601.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected PECAM1 RNA in the public colon adenocarcinoma cell groups.

Endothelial cells81.8%

Macrophages (group B)31.1%

Macrophages (group A)21.8%

Dendritic cells13.1%

B cells9.9%

Adipocytes7.8%

CD8 T cells6.9%

CD4 T cells4.6%

Natural killer cells4.0%

Tumor cells2.3%

Fibroblasts1.9%

Regulatory T cells1.8%

Granulocytes1.5%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 358. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000261371
UniProt accession: P16284
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 738
Sequence SHA-256: 986807d8fc15aaad44bf5c74e9ceb2061075622e742b1eb27cfeca7796280138

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Canonical amino-acid sequence

MQPRWAQGATMWLGVLLTLLLCSSLEGQENSFTINSVDMKSLPDWTVQNGKNLTLQCFADVSTTSHVKPQHQMLFYKDDVLFYNISSMKSTESYFIPEVRIYDSGTYKCTVIVNNKEKTTAEYQVLVEGVPSPRVTLDKKEAIQGGIVRVNCSVPEEKAPIHFTIEKLELNEKMVKLKREKNSRDQNFVILEFPVEEQDRVLSFRCQARIISGIHMQTSESTKSELVTVTESFSTPKFHISPTGMIMEGAQLHIKCTIQVTHLAQEFPEIIIQKDKAIVAHNRHGNKAVYSVMAMVEHSGNYTCKVESSRISKVSSIVVNITELFSKPELESSFTHLDQGERLNLSCSIPGAPPANFTIQKEDTIVSQTQDFTKIASKSDSGTYICTAGIDKVVKKSNTVQIVVCEMLSQPRISYDAQFEVIKGQTIEVRCESISGTLPISYQLLKTSKVLENSTKNSNDPAVFKDNPTEDVEYQCVADNCHSHAKMLSEVLRVKVIAPVDEVQISILSSKVVESGEDIVLQCAVNEGSGPITYKFYREKEGKPFYQMTSNATQAFWTKQKASKEQEGEYYCTAFNRANHASSVPRSKILTVRVILAPWKKGLIAVVIIGVIIALLIIAAKCYFLRKAKAKQMPVEMSRPAVPLLNSNNEKMSDPNMEANSHYGHNDDVRNHAMKPINDNKEPLNSDVQYTEVQVSSAESHKDLGKKDTETVYSEVRKAVPDAVESRYSRTEGSLDGT

Sequence positions 1–738

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–27

Membrane-spanning segments

602–620 (Helical)

Source-annotated domains

28–601 (Extracellular); 621–738 (Cytoplasmic)

Lipid attachment sites

622–622 (S-palmitoyl cysteine)

Source-annotated extracellular intervals

28–601

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
28	601	574	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 7403526a57e9118c1f9968c4c1c4f3c101e7528198ec7e7778e5eb8ef8df5d9b Amino-acid sequence for this intervalQENSFTINSVDMKSLPDWTVQNGKNLTLQCFADVSTTSHVKPQHQMLFYKDDVLFYNISSMKSTESYFIPEVRIYDSGTYKCTVIVNNKEKTTAEYQVLVEGVPSPRVTLDKKEAIQGGIVRVNCSVPEEKAPIHFTIEKLELNEKMVKLKREKNSRDQNFVILEFPVEEQDRVLSFRCQARIISGIHMQTSESTKSELVTVTESFSTPKFHISPTGMIMEGAQLHIKCTIQVTHLAQEFPEIIIQKDKAIVAHNRHGNKAVYSVMAMVEHSGNYTCKVESSRISKVSSIVVNITELFSKPELESSFTHLDQGERLNLSCSIPGAPPANFTIQKEDTIVSQTQDFTKIASKSDSGTYICTAGIDKVVKKSNTVQIVVCEMLSQPRISYDAQFEVIKGQTIEVRCESISGTLPISYQLLKTSKVLENSTKNSNDPAVFKDNPTEDVEYQCVADNCHSHAKMLSEVLRVKVIAPVDEVQISILSSKVVESGEDIVLQCAVNEGSGPITYKFYREKEGKPFYQMTSNATQAFWTKQKASKEQEGEYYCTAFNRANHASSVPRSKILTVRVILAPWKK

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P16284

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17580308}; Single-pass type I membrane protein {ECO:0000305}. Note=Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation. {ECO:0000269|PubMed:17580308}.; SUBCELLULAR LOCATION: [Isoform Long]: Cell membrane {ECO:0000269|PubMed:18388311, ECO:0000269|PubMed:19342684}; Single-pass type I membrane protein {ECO:0000305|PubMed:18388311}. Membrane raft {ECO:0000269|PubMed:17139370, ECO:0000269|PubMed:22496122}. Cell junction {ECO:0000269|PubMed:18388311}. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. {ECO:0000269|PubMed:19342684}.; SUBCELLULAR LOCATION: [Isoform Delta15]: Cell junction {ECO:0000269|PubMed:18388311}. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
transmembrane: TRANSMEM 602..620; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 28..601; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 621..738; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..27
lipidation: LIPID 622; /note="S-palmitoyl cysteine"; /evidence="ECO:0000269|PubMed:17139370"

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Platelet endothelial cell adhesion molecule
Protein location: Transmembrane protein
Canonical sequence: P16284 · 738 amino acids
Extracellular region: UniProt annotates extracellular residues 28–601.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in all
RNA tissue-specific nTPM: placenta: 427.4
Protein specificity: Group enriched
Protein distribution: Detected in all
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Approved
Protein tissue-specific intensity: intestine: 25,183,357.1; lung: 99,810,087.1; lymphoid tissue: 42,656,235.7
Tissue cell-type enrichment: Adipose subcutaneous - Endothelial cells, Adipose visceral - Endothelial cells, Adrenal gland - Endothelial cells, Breast - Endothelial cells, Colon - Endothelial cells, Heart muscle - Endothelial cells, Kidney - Endothelial cells, Liver - Vascular endothelial cells, Lung - Endothelial cells, Minor Salivary Gland - Endothelial cells, Pancreas - Endothelial cells, Pituitary gland - Endothelial cells, Prostate - Endothelial cells, Skeletal muscle - Endothelial cells, Stomach - Endothelial cells, Testis - Endothelial cells, Thyroid gland - Endothelial cells
Subcellular location: Nucleoli, Plasma membrane

Human Protein Atlas: PECAM1

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

PECAM1 · ENSG00000261371 · P16284