PIK3CG

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. The canonical sequence contains 1,102 amino acids.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected PIK3CG RNA in the public colon adenocarcinoma cell groups.

Dendritic cells9.2%

B cells7.8%

Macrophages (group B)6.4%

Macrophages (group A)5.3%

Granulocytes4.3%

Natural killer cells4.3%

CD8 T cells4.1%

CD4 T cells3.1%

Regulatory T cells2.8%

Endothelial cells1.4%

Tumor cells0.4%

Fibroblasts0.3%

Adipocytes0.2%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 215. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000105851
UniProt accession: P48736
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 1102
Sequence SHA-256: 8caecf83dffab0bac6b72623e6a7428c5a8cc791b0858bcc7f1f4bc67a8bed5b

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Canonical amino-acid sequence

MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA

This collection has no explicit extracellular interval for this protein.

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P48736

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subcellular_location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12163475}. Cell membrane {ECO:0000269|PubMed:12163475}.
transmembrane: Not recorded
topological_domain: Not recorded
signal_peptide: Not recorded
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Protein location: Cytoplasm and cell membrane
Canonical sequence: P48736 · 1,102 amino acids

Expression in normal tissues

RNA specificity: Group enriched
RNA distribution: Detected in many
RNA tissue-specific nTPM: bone marrow: 41.2; lymphoid tissue: 18.4
Protein specificity: Group enriched
Protein distribution: Detected in some
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: intestine: 2,145,048.4; lymphoid tissue: 1,880,533.2
Tissue cell-type enrichment: Adrenal gland - Macrophages, Testis - Early spermatids, Testis - Spermatocytes
Subcellular location: Plasma membrane

Human Protein Atlas: PIK3CG

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

PIK3CG · ENSG00000105851 · P48736