PLAUR

Urokinase plasminogen activator surface receptor. An extracellular span at residues 23–304 is derived from the signal peptide and GPI attachment annotation.

Predicted protein structure

A downloaded AlphaFold model connects the PLAUR sequence to its predicted three-dimensional structure.

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RNA expression by cell type

Percentage of cells with detected PLAUR RNA in the public colon adenocarcinoma cell groups.

Macrophages (group B)50.9%

Macrophages (group A)45.6%

Granulocytes30.5%

Fibroblasts24.4%

Tumor cells19.1%

Endothelial cells13.9%

Dendritic cells11.8%

Adipocytes7.6%

CD4 T cells3.7%

Natural killer cells2.4%

Regulatory T cells2.3%

B cells2.1%

CD8 T cells1.4%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 101. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000011422
UniProt accession: Q03405
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 335
Sequence SHA-256: 6ef31e1bc4afc523da622ec2732076c498b9cc99c8c3eeeeb5ef020dc9490d89

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Canonical amino-acid sequence

MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT

Sequence positions 1–335

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–22

Lipid attachment sites

305–305 (GPI-anchor amidated glycine)

Derived extracellular interval

23–304

The extracellular interval is derived from the signal peptide and GPI attachment site. It is a proposed construct interval.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
23	304	282	Sequence and source Basis interval-after-reviewed-signal-before-reviewed-gpi-anchor Evidence class topology-derived-construct-hypothesis Sequence SHA-256 ea3f2f88c2cbbc14040bc4c4571bcc9078442b2e641891c8f8e757a558cbc389 Amino-acid sequence for this intervalLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRS

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q03405

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subcellular_location: SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:12376466}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:28849762}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:12376466}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:28849762}. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. {ECO:0000269|PubMed:12376466}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000250|UniProtKB:P49616}.
transmembrane: Not recorded
topological_domain: Not recorded
signal_peptide: SIGNAL 1..22; /evidence="ECO:0000269|PubMed:1689240"
lipidation: LIPID 305; /note="GPI-anchor amidated glycine"; /evidence="ECO:0000255"

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Urokinase plasminogen activator surface receptor
Protein location: GPI-anchored membrane protein
Canonical sequence: Q03405 · 335 amino acids
Extracellular region: An extracellular span at residues 23–304 is derived from the signal peptide and GPI attachment annotation.

Expression in normal tissues

RNA specificity: Tissue enriched
RNA distribution: Detected in all
RNA tissue-specific nTPM: bone marrow: 650.6
Protein specificity: Group enriched
Protein distribution: Detected in many
Immunohistochemistry reliability: Uncertain
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: lung: 239,926.9; salivary gland: 117,579.5
Tissue cell-type enrichment: Minor Salivary Gland - Minor salivary glandular cells, Thyroid gland - Neutrophils
Subcellular location: Plasma membrane

Human Protein Atlas: PLAUR

Structures

A predicted target model is available.

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Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

PLAUR · ENSG00000011422 · Q03405