PLVAP

Plasmalemma vesicle-associated protein. UniProt annotates extracellular residues 49–442.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected PLVAP RNA in the public colon adenocarcinoma cell groups.

Endothelial cells73.7%

Adipocytes5.9%

Dendritic cells5.2%

Macrophages (group B)3.2%

Fibroblasts2.2%

Tumor cells2.1%

B cells1.5%

Natural killer cells1.2%

Regulatory T cells1.1%

CD4 T cells1.1%

Macrophages (group A)1.1%

Granulocytes1.0%

CD8 T cells1.0%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 657. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000130300
UniProt accession: Q9BX97
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 442
Sequence SHA-256: 2647faacd277934cdb68d42958afebf6807a736c56550a20fff607d8e730055f

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Canonical amino-acid sequence

MGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG

Sequence positions 1–442

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments

28–48 (Helical; Signal-anchor for type II membrane protein)

Source-annotated domains

1–27 (Cytoplasmic); 49–442 (Extracellular)

Source-annotated extracellular intervals

49–442

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
49	442	394	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 594e16597ef952469aee7bf88448ce7d8a87e94bc245b9c0b1caa9d0254b4e0b Amino-acid sequence for this intervalYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q9BX97

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9WV78}; Single-pass type II membrane protein {ECO:0000255}. Membrane, caveola {ECO:0000250|UniProtKB:Q9WV78}; Single-pass type II membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9WV78}. Note=Membrane-associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region. {ECO:0000250|UniProtKB:Q9WV78}.
transmembrane: TRANSMEM 28..48; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 1..27; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 49..442; /note="Extracellular"; /evidence="ECO:0000255"
signal_peptide: Not recorded
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Plasmalemma vesicle-associated protein
Protein location: Transmembrane protein
Canonical sequence: Q9BX97 · 442 amino acids
Extracellular region: UniProt annotates extracellular residues 49–442.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: thyroid gland: 419.4
Protein specificity: Tissue enriched
Protein distribution: Detected in many
Immunohistochemistry reliability: Supported
Immunofluorescence reliability: Approved
Protein tissue-specific intensity: intestine: 8,541,951.3
Tissue cell-type enrichment: Adipose subcutaneous - Endothelial cells, Adipose visceral - Endothelial cells, Adrenal gland - Endothelial cells, Breast - Endothelial cells, Colon - Endothelial cells, Kidney - Endothelial cells, Liver - Vascular endothelial cells, Minor Salivary Gland - Endothelial cells, Pituitary gland - Endothelial cells, Prostate - Endothelial cells, Skeletal muscle - Endothelial cells, Stomach - Endothelial cells, Thyroid gland - Endothelial cells
Subcellular location: Cytosol

Human Protein Atlas: PLVAP

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

PLVAP · ENSG00000130300 · Q9BX97