PTK7

Inactive tyrosine-protein kinase 7. UniProt annotates extracellular residues 31–704.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected PTK7 RNA in the public colon adenocarcinoma cell groups.

Fibroblasts23.9%

Endothelial cells7.9%

Adipocytes5.0%

Dendritic cells3.9%

Tumor cells2.5%

Macrophages (group B)0.6%

Macrophages (group A)0.5%

CD8 T cells0.5%

Regulatory T cells0.4%

Natural killer cells0.2%

B cells0.2%

CD4 T cells0.2%

Granulocytes0.2%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 286. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000112655
UniProt accession: Q13308
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 1070
Sequence SHA-256: ccbd8104cd4096ca3127315d99235a841babf5b8275a7ec7b7316773b5b0636d

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Canonical amino-acid sequence

MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP

Sequence positions 1–1070

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–30

Membrane-spanning segments

705–725 (Helical)

Source-annotated domains

31–704 (Extracellular); 726–1070 (Cytoplasmic)

Source-annotated extracellular intervals

31–704

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
31	704	674	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 b4cec77951d35cbfaa83e65434475eb9f6ee16840bfc517d7d92f009e93f8449 Amino-acid sequence for this intervalAIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQT

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q13308

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20837484}; Single-pass type I membrane protein {ECO:0000255}. Cell junction {ECO:0000269|PubMed:20837484}. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells. {ECO:0000269|PubMed:20837484}.
transmembrane: TRANSMEM 705..725; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 31..704; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 726..1070; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..30; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Inactive tyrosine-protein kinase 7
Protein location: Transmembrane protein
Canonical sequence: Q13308 · 1,070 amino acids
Extracellular region: UniProt annotates extracellular residues 31–704.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in many
Protein specificity: Tissue enhanced
Protein distribution: Detected in many
Immunohistochemistry reliability: Approved
Immunofluorescence reliability: Approved
Protein tissue-specific intensity: ovary: 162,307,920.6
Tissue cell-type enrichment: Adipose subcutaneous - Adipose progenitor cells, Heart muscle - Fibroblasts, Skeletal muscle - Fibroblasts, Testis - Late spermatids
Subcellular location: Plasma membrane, Cytosol

Human Protein Atlas: PTK7

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

PTK7 · ENSG00000112655 · Q13308