PTPRC

Receptor-type tyrosine-protein phosphatase C. UniProt annotates extracellular residues 26–577.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected PTPRC RNA in the public colon adenocarcinoma cell groups.

Regulatory T cells80.0%

CD8 T cells76.1%

CD4 T cells65.1%

Natural killer cells64.4%

Macrophages (group A)53.1%

Macrophages (group B)51.8%

Dendritic cells38.6%

B cells36.2%

Granulocytes27.6%

Adipocytes2.3%

Fibroblasts2.0%

Endothelial cells2.0%

Tumor cells2.0%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 89. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000081237
UniProt accession: P08575
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 1306
Sequence SHA-256: b0ce0e4d7fe877d892127ded1065394926dfbc5f99908525083ec48b94cbec06

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Canonical amino-acid sequence

MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS

Sequence positions 1–1306

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–25

Membrane-spanning segments

578–598 (Helical)

Source-annotated domains

26–577 (Extracellular); 599–1306 (Cytoplasmic)

Source-annotated extracellular intervals

26–577

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
26	577	552	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 6d8a175cb4e0d44e8e1b795aa342816c6c19ae6769966d3b5a72e5e56c125fed Amino-acid sequence for this intervalQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSK

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P08575

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12676959, ECO:0000269|PubMed:22174689}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:12676959}. Synapse {ECO:0000269|PubMed:35767951}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269|PubMed:12676959}.
transmembrane: TRANSMEM 578..598; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 26..577; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 599..1306; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..25
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Receptor-type tyrosine-protein phosphatase C
Protein location: Transmembrane protein
Canonical sequence: P08575 · 1,306 amino acids
Extracellular region: UniProt annotates extracellular residues 26–577.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in all
RNA tissue-specific nTPM: lymphoid tissue: 273.8
Protein specificity: Tissue enriched
Protein distribution: Detected in many
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Uncertain
Protein tissue-specific intensity: lymphoid tissue: 171,192,495.2
Tissue cell-type enrichment: Adipose visceral - T-cells, Adrenal gland - Macrophages, Breast - T-cells, Kidney - T-cells, Lung - NK-cells (Lung), Prostate - T-cells, Skin - T-cells, Thyroid gland - T-cells
Subcellular location: Nucleoplasm, Vesicles

Human Protein Atlas: PTPRC

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

PTPRC · ENSG00000081237 · P08575