Surface AtlasMucinous colon cancer

PVRL2

Nectin-2. UniProt annotates extracellular residues 32–360.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected PVRL2 RNA in the public colon adenocarcinoma cell groups.

Endothelial cells51.6%
Fibroblasts31.1%
Macrophages (group B)25.2%
Tumor cells24.5%
Dendritic cells21.6%
Adipocytes12.6%
Macrophages (group A)10.7%
Granulocytes3.3%
CD4 T cells1.2%
Natural killer cells1.2%
Regulatory T cells1.1%
B cells1.1%
CD8 T cells0.6%
RNA detection · Cancer Surfaceome Atlas, Table S6, row 647. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000130202
UniProt accession
Q92692
Sequence state
available
Canonical sequence
Yes
Length in amino acids
538
Sequence SHA-256
bd2066ba5401010a36293bfa215a576dd5085e781b5d7d4c7b8f8ea76049d215
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Sequence positions 1–538

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide
1–31
1–31
Membrane-spanning segments
361–381: Helical
361–381 (Helical)
Source-annotated domains
32–360: Extracellular382–538: Cytoplasmic
32–360 (Extracellular); 382–538 (Cytoplasmic)
Source-annotated extracellular intervals
32–360
32–360

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
32360329
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
636f5069b44a0a67b76e1cc5dc69b7660782dccfae2230604e66e729c5c62834
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

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Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
Q92692

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subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
transmembrane
TRANSMEM 361..381; /note="Helical"; /evidence="ECO:0000255"
topological_domain
TOPO_DOM 32..360; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 382..538; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide
SIGNAL 1..31; /evidence="ECO:0000255"
lipidation
Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
Nectin-2
Protein location
Transmembrane protein
Canonical sequence
Q92692 · 538 amino acids
Extracellular region
UniProt annotates extracellular residues 32–360.

Expression in normal tissues

RNA specificity
Low tissue specificity
RNA distribution
Detected in all
Protein specificity
Low tissue specificity
Protein distribution
Detected in all
Immunohistochemistry reliability
Enhanced
Immunofluorescence reliability
Approved
Tissue cell-type enrichment
Adipose subcutaneous - Endothelial cells, Adrenal gland - Adrenal cortex cells, Breast - Breast glandular cells, Colon - Endothelial cells, Minor Salivary Gland - Minor salivary glandular cells, Prostate - Prostate glandular cells, Skeletal muscle - Endothelial cells
Subcellular location
Vesicles

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

PVRL2 · ENSG00000130202 · Q92692

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