SELL

L-selectin. UniProt annotates extracellular residues 39–332.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected SELL RNA in the public colon adenocarcinoma cell groups.

Regulatory T cells33.8%

Dendritic cells23.5%

CD4 T cells19.3%

B cells15.9%

Macrophages (group A)14.6%

Natural killer cells11.4%

CD8 T cells9.2%

Macrophages (group B)4.5%

Endothelial cells4.2%

Granulocytes3.6%

Adipocytes0.8%

Fibroblasts0.6%

Tumor cells0.6%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 116. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000188404
UniProt accession: P14151
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 372
Sequence SHA-256: 28ea52e4a2c9c8a43fc8f2ae203a75cf1c7e0bc0aec5158bcfa6c333d613342d

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Canonical amino-acid sequence

MIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGKKSKRSMNDPY

Sequence positions 1–372

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–28

Membrane-spanning segments

333–355 (Helical)

Source-annotated domains

39–332 (Extracellular); 356–372 (Cytoplasmic)

Source-annotated extracellular intervals

39–332

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
39	332	294	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 36477a3ba9a0d8282cfaa59604eba0bcf67312c19f5cc6719a00607458c332bd Amino-acid sequence for this intervalWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYN

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P14151

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2509939, ECO:0000269|PubMed:2663882, ECO:0000269|PubMed:28011641}; Single-pass type I membrane protein {ECO:0000305|PubMed:2663882}.
transmembrane: TRANSMEM 333..355; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 39..332; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 356..372; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..28
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: L-selectin
Protein location: Transmembrane protein
Canonical sequence: P14151 · 372 amino acids
Extracellular region: UniProt annotates extracellular residues 39–332.

Expression in normal tissues

RNA specificity: Group enriched
RNA distribution: Detected in many
RNA tissue-specific nTPM: bone marrow: 142.1; lymphoid tissue: 216.7
Protein specificity: Low tissue specificity
Protein distribution: Detected in many
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Uncertain
Tissue cell-type enrichment: Adipose visceral - Neutrophils, Heart muscle - Neutrophils, Liver - Neutrophils, Lung - Neutrophils_2, Skeletal muscle - Neutrophils, Spleen - Neutrophils_2
Subcellular location: Cytosol

Human Protein Atlas: SELL

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

SELL · ENSG00000188404 · P14151