Surface AtlasMucinous colon cancer

SLC2A1

Solute carrier family 2, facilitated glucose transporter member 1. UniProt annotates extracellular residues 34–66, 113–120, 177–185, 294–306, 356–365, 423–429.

Sequence and protein regions

Explore the SLC2A1 sequence, select annotated regions, and copy a request to continue in Codex.

Open this view

RNA expression by cell type

Percentage of cells with detected SLC2A1 RNA in the public colon adenocarcinoma cell groups.

Tumor cells24.4%
Dendritic cells15.0%
Fibroblasts7.8%
Macrophages (group B)6.7%
Natural killer cells5.5%
Endothelial cells4.0%
CD8 T cells3.4%
B cells3.4%
Macrophages (group A)3.1%
CD4 T cells2.8%
Regulatory T cells2.5%
Granulocytes1.2%
Adipocytes1.2%
RNA detection · Cancer Surfaceome Atlas, Table S6, row 37. Source study · Measurements (JSON)

Sequence & binding sites

Choose a protein region, search amino-acid letters, or inspect a recorded binding site.

Loading sequence…

Open the sequence explorer
Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000117394
UniProt accession
P11166
Sequence state
available
Canonical sequence
Yes
Length in amino acids
492
Sequence SHA-256
cc16edbc0d573ad46f7962c2fe3e99ac43b7c21d34fb1928ce67f24cc951f022
View and select the full canonical sequence
Sequence positions 1–492

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments
12–33: Helical; Name=167–87: Helical; Name=291–112: Helical; Name=3121–144: Helical; Name=4156–176: Helical; Name=5186–206: Helical; Name=6272–293: Helical; Name=7307–328: Helical; Name=8335–355: Helical; Name=9366–388: Helical; Name=10402–422: Helical; Name=11430–450: Helical; Name=12
12–33 (Helical; Name=1); 67–87 (Helical; Name=2); 91–112 (Helical; Name=3); 121–144 (Helical; Name=4); 156–176 (Helical; Name=5); 186–206 (Helical; Name=6); 272–293 (Helical; Name=7); 307–328 (Helical; Name=8); 335–355 (Helical; Name=9); 366–388 (Helical; Name=10); 402–422 (Helical; Name=11); 430–450 (Helical; Name=12)
Source-annotated domains
1–11: Cytoplasmic34–66: Extracellular88–90: Cytoplasmic113–120: Extracellular145–155: Cytoplasmic177–185: Extracellular207–271: Cytoplasmic294–306: Extracellular329–334: Cytoplasmic356–365: Extracellular389–401: Cytoplasmic423–429: Extracellular451–492: Cytoplasmic
1–11 (Cytoplasmic); 34–66 (Extracellular); 88–90 (Cytoplasmic); 113–120 (Extracellular); 145–155 (Cytoplasmic); 177–185 (Extracellular); 207–271 (Cytoplasmic); 294–306 (Extracellular); 329–334 (Cytoplasmic); 356–365 (Extracellular); 389–401 (Cytoplasmic); 423–429 (Extracellular); 451–492 (Cytoplasmic)
Source-annotated extracellular intervals
34–66113–120177–185294–306356–365423–429
34–66; 113–120; 177–185; 294–306; 356–365; 423–429

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
346633
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
6e2473a2ab98ccf216c718175564827339d325f1028de78a3fc8835b929b527c
1131208
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
4b5ba6a97f4a5bc6aa7cbfbbe71578db26069d0921e1632584d14c4cb9e15583
1771859
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
9bae8ac855c964294ec8fb15275354498a33a84a3855f08d1aaf83e3a28ef90e
29430613
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
b8bb91ecae3d857b8a56345e9edf57ac1f1937f1b57ec59251d8654841527ba9
35636510
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
0e103a1cf5909de645a3b9158d026c497b8a0959a8c6bfbcb0c5344f64f06928
4234297
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
e1bcace4f0db858252c6056f3a1d9a76ea1c00169c0044e6af3d0852357f3ca8
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

Download source snapshot

Open sequence source
Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
P11166

Download source snapshot (gzip)

subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18245775, ECO:0000269|PubMed:19449892, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:24847886, ECO:0000269|PubMed:25982116, ECO:0000269|PubMed:30197081}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000269|PubMed:17081065}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P17809}. Note=Localizes primarily at the cell surface (PubMed:18245775, PubMed:19449892, PubMed:23219802, PubMed:24847886, PubMed:25982116). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:18245775, ECO:0000269|PubMed:19449892, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:24847886, ECO:0000269|PubMed:25982116}.
transmembrane
TRANSMEM 12..33; /note="Helical; Name=1"; TRANSMEM 67..87; /note="Helical; Name=2"; TRANSMEM 91..112; /note="Helical; Name=3"; TRANSMEM 121..144; /note="Helical; Name=4"; TRANSMEM 156..176; /note="Helical; Name=5"; TRANSMEM 186..206; /note="Helical; Name=6"; TRANSMEM 272..293; /note="Helical; Name=7"; TRANSMEM 307..328; /note="Helical; Name=8"; TRANSMEM 335..355; /note="Helical; Name=9"; TRANSMEM 366..388; /note="Helical; Name=10"; TRANSMEM 402..422; /note="Helical; Name=11"; TRANSMEM 430..450; /note="Helical; Name=12"
topological_domain
TOPO_DOM 1..11; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:24847886"; TOPO_DOM 34..66; /note="Extracellular"; /evidence="ECO:0000269|PubMed:24847886"; TOPO_DOM 88..90; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:24847886"; TOPO_DOM 113..120; /note="Extracellular"; /evidence="ECO:0000269|PubMed:24847886"; TOPO_DOM 145..155; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:24847886"; TOPO_DOM 177..185; /note="Extracellular"; /evidence="ECO:0000269|PubMed:24847886"; TOPO_DOM 207..271; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:24847886"; TOPO_DOM 294..306; /note="Extracellular"; /evidence="ECO:0000269|PubMed:24847886"; TOPO_DOM 329..334; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:24847886"; TOPO_DOM 356..365; /note="Extracellular"; /evidence="ECO:0000269|PubMed:24847886"; TOPO_DOM 389..401; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:24847886"; TOPO_DOM 423..429; /note="Extracellular"; /evidence="ECO:0000269|PubMed:24847886"; TOPO_DOM 451..492; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:24847886"
signal_peptide
Not recorded
lipidation
Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
Solute carrier family 2, facilitated glucose transporter member 1
Protein location
Transmembrane protein
Canonical sequence
P11166 · 492 amino acids
Extracellular region
UniProt annotates extracellular residues 34–66, 113–120, 177–185, 294–306, 356–365, 423–429.

Expression in normal tissues

RNA specificity
Tissue enhanced
RNA distribution
Detected in many
RNA tissue-specific nTPM
placenta: 92.7
Protein specificity
Low tissue specificity
Protein distribution
Detected in all
Immunohistochemistry reliability
Enhanced
Immunofluorescence reliability
Enhanced
Tissue cell-type enrichment
Minor Salivary Gland - Minor salivary gland basal cells
Subcellular location
Plasma membrane

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

SLC2A1 · ENSG00000117394 · P11166

Search the report