Surface AtlasMucinous colon cancer

SLC34A2

Sodium-dependent phosphate transport protein 2B. UniProt annotates extracellular residues 122–135, 234–362, 429–485, 547–552.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected SLC34A2 RNA in the public colon adenocarcinoma cell groups.

Adipocytes0.1%
Endothelial cells0.044%
Tumor cells0.039%
B cells0.0%
Dendritic cells0.0%
Fibroblasts0.0%
Granulocytes0.0%
Macrophages (group A)0.0%
Macrophages (group B)0.0%
Natural killer cells0.0%
CD4 T cells0.0%
CD8 T cells0.0%
Regulatory T cells0.0%
RNA detection · Cancer Surfaceome Atlas, Table S6, row 335. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000157765
UniProt accession
O95436
Sequence state
available
Canonical sequence
Yes
Length in amino acids
690
Sequence SHA-256
33ce6c59e28a7373fce51debe32cec8d891ef691c2e77a0655a74040da25eef9
View and select the full canonical sequence
Sequence positions 1–690

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments
101–121: Helical; Name=M1136–156: Helical; Name=M2213–233: Helical; Name=M3363–383: Helical; Name=M4408–428: Helical; Name=M5486–506: Helical; Name=M6526–546: Helical; Name=M7553–573: Helical; Name=M8
101–121 (Helical; Name=M1); 136–156 (Helical; Name=M2); 213–233 (Helical; Name=M3); 363–383 (Helical; Name=M4); 408–428 (Helical; Name=M5); 486–506 (Helical; Name=M6); 526–546 (Helical; Name=M7); 553–573 (Helical; Name=M8)
Source-annotated domains
1–100: Cytoplasmic122–135: Extracellular157–212: Cytoplasmic234–362: Extracellular384–407: Cytoplasmic429–485: Extracellular507–525: Cytoplasmic547–552: Extracellular574–689: Cytoplasmic
1–100 (Cytoplasmic); 122–135 (Extracellular); 157–212 (Cytoplasmic); 234–362 (Extracellular); 384–407 (Cytoplasmic); 429–485 (Extracellular); 507–525 (Cytoplasmic); 547–552 (Extracellular); 574–689 (Cytoplasmic)
Source-annotated extracellular intervals
122–135234–362429–485547–552
122–135; 234–362; 429–485; 547–552

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
12213514
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
ad2b2d50fc80017ad71946812d9f32419570087c74ddcb173b5253f6befa78b0
234362129
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
964c4be47604821cc47f72af73331a636eb688d839c7638b76b1e93fc956b9ea
42948557
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
0183894c145574f200dbc96b2c6fb3fed24619d7eafea9431d7ed7f7def64057
5475526
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
bc776b938b925066f4d91cc281af61e0e7941842d7c16305f7762718c499ccbd
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

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Open sequence source
Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
O95436

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subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9DBP0}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membranes of enterocytes. {ECO:0000250|UniProtKB:Q9DBP0}.
transmembrane
TRANSMEM 101..121; /note="Helical; Name=M1"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical; Name=M2"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical; Name=M3"; /evidence="ECO:0000255"; TRANSMEM 363..383; /note="Helical; Name=M4"; /evidence="ECO:0000255"; TRANSMEM 408..428; /note="Helical; Name=M5"; /evidence="ECO:0000255"; TRANSMEM 486..506; /note="Helical; Name=M6"; /evidence="ECO:0000255"; TRANSMEM 526..546; /note="Helical; Name=M7"; /evidence="ECO:0000255"; TRANSMEM 553..573; /note="Helical; Name=M8"; /evidence="ECO:0000255"
topological_domain
TOPO_DOM 1..100; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 122..135; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 157..212; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 234..362; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 384..407; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 429..485; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 507..525; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 547..552; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 574..689; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide
Not recorded
lipidation
Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
Sodium-dependent phosphate transport protein 2B
Protein location
Transmembrane protein
Canonical sequence
O95436 · 690 amino acids
Extracellular region
UniProt annotates extracellular residues 122–135, 234–362, 429–485, 547–552.

Expression in normal tissues

RNA specificity
Tissue enriched
RNA distribution
Detected in many
RNA tissue-specific nTPM
lung: 709.6
Protein specificity
Tissue enriched
Protein distribution
Detected in some
Immunohistochemistry reliability
Enhanced
Immunofluorescence reliability
Supported
Protein tissue-specific intensity
lung: 12,230,182.5
Tissue cell-type enrichment
Kidney - Macrophages, Lung - Alveolar cells type 2, Minor Salivary Gland - Minor salivary glandular cells, Testis - Early spermatids, Testis - Late spermatids
Subcellular location
Plasma membrane

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

SLC34A2 · ENSG00000157765 · O95436

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