Surface AtlasMucinous colon cancer

SLC7A5

Large neutral amino acids transporter small subunit 1. UniProt annotates extracellular residues 71–83, 148–169, 215–242, 298–324, 391–395, 452–457.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected SLC7A5 RNA in the public colon adenocarcinoma cell groups.

Dendritic cells17.0%
Tumor cells7.1%
Regulatory T cells6.8%
CD8 T cells6.7%
Granulocytes5.0%
CD4 T cells4.6%
Macrophages (group B)4.5%
Macrophages (group A)4.1%
B cells4.1%
Natural killer cells3.3%
Fibroblasts1.7%
Endothelial cells1.5%
Adipocytes1.0%
RNA detection · Cancer Surfaceome Atlas, Table S6, row 33. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000103257
UniProt accession
Q01650
Sequence state
available
Canonical sequence
Yes
Length in amino acids
507
Sequence SHA-256
4cefddb471e4fa81075cb5a14ca59a3f498177df13692fc3b4c5e7c2a0666166
View and select the full canonical sequence
Sequence positions 1–507

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments
50–70: Helical84–104: Helical127–147: Helical170–190: Helical193–214: Helical243–263: Helical277–297: Helical325–345: Helical370–390: Helical396–416: Helical431–451: Helical458–478: Helical
50–70 (Helical); 84–104 (Helical); 127–147 (Helical); 170–190 (Helical); 193–214 (Helical); 243–263 (Helical); 277–297 (Helical); 325–345 (Helical); 370–390 (Helical); 396–416 (Helical); 431–451 (Helical); 458–478 (Helical)
Source-annotated domains
1–49: Cytoplasmic71–83: Extracellular105–126: Cytoplasmic148–169: Extracellular191–192: Cytoplasmic215–242: Extracellular264–276: Cytoplasmic298–324: Extracellular346–369: Cytoplasmic391–395: Extracellular417–430: Cytoplasmic452–457: Extracellular479–507: Cytoplasmic
1–49 (Cytoplasmic); 71–83 (Extracellular); 105–126 (Cytoplasmic); 148–169 (Extracellular); 191–192 (Cytoplasmic); 215–242 (Extracellular); 264–276 (Cytoplasmic); 298–324 (Extracellular); 346–369 (Cytoplasmic); 391–395 (Extracellular); 417–430 (Cytoplasmic); 452–457 (Extracellular); 479–507 (Cytoplasmic)
Source-annotated extracellular intervals
71–83148–169215–242298–324391–395452–457
71–83; 148–169; 215–242; 298–324; 391–395; 452–457

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
718313
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
fac952c3800e00113fc0f8bbcd208eaa563265296ba06e41fb616fdf7e27bb17
14816922
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
140fac0c8827453fe27106b7f4fbd0ddf9ba290caae5c6bdee03b40374dff676
21524228
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
37ecb5e0471001009275b695d33741146dc660c8ab555e1d8a9b309e733dc977
29832427
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
6c82e9018e70883db52f319bdf37d538a6acbc60de2c33140786e726552edb79
3913955
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
9e367cc41b00ce47aee48c1dc398aeddde81de690ada7053ba6e717d7c3c0734
4524576
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
38fe9b715f841f1933a9a2c9fc7a1f9c92c07fe1abb0829fe8549ddfe0d1744c
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

Download source snapshot

Open sequence source
Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
Q01650

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subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:11742812}; Multi-pass membrane protein {ECO:0000269|PubMed:30867591}. Cell membrane {ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:9751058}; Multi-pass membrane protein {ECO:0000269|PubMed:30867591}. Lysosome membrane {ECO:0000269|PubMed:25998567}; Multi-pass membrane protein {ECO:0000305|PubMed:25998567}. Note=Located to the plasma membrane by SLC3A2/4F2hc (PubMed:9751058). Localized to the apical membrane of placental syncytiotrophoblastic cells (PubMed:11742812). Recruited to lysosomes by LAPTM4B (PubMed:25998567). {ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:9751058}.
transmembrane
TRANSMEM 50..70; /note="Helical"; /evidence="ECO:0000269|PubMed:30867591"; TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000269|PubMed:30867591"; TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000269|PubMed:30867591"; TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000269|PubMed:30867591"; TRANSMEM 193..214; /note="Helical"; /evidence="ECO:0000269|PubMed:30867591"; TRANSMEM 243..263; /note="Helical"; /evidence="ECO:0000269|PubMed:30867591"; TRANSMEM 277..297; /note="Helical"; /evidence="ECO:0000269|PubMed:30867591"; TRANSMEM 325..345; /note="Helical"; /evidence="ECO:0000269|PubMed:30867591"; TRANSMEM 370..390; /note="Helical"; /evidence="ECO:0000269|PubMed:30867591"; TRANSMEM 396..416; /note="Helical"; /evidence="ECO:0000269|PubMed:30867591"; TRANSMEM 431..451; /note="Helical"; /evidence="ECO:0000269|PubMed:30867591"; TRANSMEM 458..478; /note="Helical"; /evidence="ECO:0000269|PubMed:30867591"
topological_domain
TOPO_DOM 1..49; /note="Cytoplasmic"; /evidence="ECO:0000305"; TOPO_DOM 71..83; /note="Extracellular"; /evidence="ECO:0000305"; TOPO_DOM 105..126; /note="Cytoplasmic"; /evidence="ECO:0000305"; TOPO_DOM 148..169; /note="Extracellular"; /evidence="ECO:0000305"; TOPO_DOM 191..192; /note="Cytoplasmic"; /evidence="ECO:0000305"; TOPO_DOM 215..242; /note="Extracellular"; /evidence="ECO:0000305"; TOPO_DOM 264..276; /note="Cytoplasmic"; /evidence="ECO:0000305"; TOPO_DOM 298..324; /note="Extracellular"; /evidence="ECO:0000305"; TOPO_DOM 346..369; /note="Cytoplasmic"; /evidence="ECO:0000305"; TOPO_DOM 391..395; /note="Extracellular"; /evidence="ECO:0000305"; TOPO_DOM 417..430; /note="Cytoplasmic"; /evidence="ECO:0000305"; TOPO_DOM 452..457; /note="Extracellular"; /evidence="ECO:0000305"; TOPO_DOM 479..507; /note="Cytoplasmic"; /evidence="ECO:0000305"
signal_peptide
Not recorded
lipidation
Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
Large neutral amino acids transporter small subunit 1
Protein location
Transmembrane protein
Canonical sequence
Q01650 · 507 amino acids
Extracellular region
UniProt annotates extracellular residues 71–83, 148–169, 215–242, 298–324, 391–395, 452–457.

Expression in normal tissues

RNA specificity
Tissue enhanced
RNA distribution
Detected in all
RNA tissue-specific nTPM
bone marrow: 104.4; esophagus: 96.2
Protein specificity
Tissue enriched
Protein distribution
Detected in some
Immunohistochemistry reliability
Approved
Immunofluorescence reliability
Supported
Protein tissue-specific intensity
cerebral cortex: 9,198,948.9
Tissue cell-type enrichment
Testis - Sertoli cells
Subcellular location
Plasma membrane, Cytosol

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

SLC7A5 · ENSG00000103257 · Q01650

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