SRC

Proto-oncogene tyrosine-protein kinase Src. The canonical sequence contains 536 amino acids.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected SRC RNA in the public colon adenocarcinoma cell groups.

Tumor cells8.8%

Macrophages (group B)8.2%

Fibroblasts6.4%

Dendritic cells5.9%

Macrophages (group A)5.6%

Adipocytes2.9%

Granulocytes1.7%

B cells0.8%

Regulatory T cells0.8%

Natural killer cells0.5%

Endothelial cells0.4%

CD4 T cells0.4%

CD8 T cells0.3%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 144. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000197122
UniProt accession: P12931
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 536
Sequence SHA-256: bfb0c691493b552212f52a3e68ec9d6c2e67dc37339f19b6e71c22fd202292f8

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Canonical amino-acid sequence

MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL

Sequence positions 1–536

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Lipid attachment sites

2–2 (N-myristoyl glycine)

This collection has no explicit extracellular interval for this protein.

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P12931

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7525268}; Lipid-anchor {ECO:0000269|PubMed:22801373}. Mitochondrion inner membrane {ECO:0000269|PubMed:12615910}. Nucleus {ECO:0000269|PubMed:7853507}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:7525268}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19307596}. Cell junction, focal adhesion {ECO:0000269|PubMed:22801373}. Cell junction {ECO:0000269|PubMed:22294297}. Note=Localizes to focal adhesion sites following integrin engagement (PubMed:22801373). Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268). Colocalizes with PDLIM4 at the perinuclear region, but not at focal adhesions (PubMed:19307596). {ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:22801373, ECO:0000269|PubMed:7525268}.
transmembrane: Not recorded
topological_domain: Not recorded
signal_peptide: Not recorded
lipidation: LIPID 2; /note="N-myristoyl glycine"; /evidence="ECO:0000269|PubMed:7525268"

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Proto-oncogene tyrosine-protein kinase Src
Protein location: Lipid-anchored at the cell membrane
Canonical sequence: P12931 · 536 amino acids

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in many
Protein specificity: Low tissue specificity
Protein distribution: Detected in many
Immunohistochemistry reliability: Approved
Immunofluorescence reliability: Supported
Tissue cell-type enrichment: Spleen - Macrophages, Stomach - Gastric mucous cells, Testis - Sertoli cells
Subcellular location: Vesicles, Plasma membrane, Cell Junctions

Human Protein Atlas: SRC

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

SRC · ENSG00000197122 · P12931