TGFBR2

TGF-beta receptor type-2. UniProt annotates extracellular residues 23–166.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected TGFBR2 RNA in the public colon adenocarcinoma cell groups.

Endothelial cells66.2%

Fibroblasts35.0%

Macrophages (group B)29.0%

Adipocytes23.9%

Dendritic cells19.6%

Macrophages (group A)18.1%

Tumor cells12.7%

Granulocytes12.3%

CD8 T cells12.1%

CD4 T cells11.0%

Natural killer cells9.7%

B cells8.2%

Regulatory T cells7.9%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 140. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000163513
UniProt accession: P37173
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 567
Sequence SHA-256: 1b068d99d6e43ba9318cb12b365fd9c97d0d130eb86a631b82664c3776e8ae94

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Canonical amino-acid sequence

MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK

Sequence positions 1–567

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–22

Membrane-spanning segments

167–187 (Helical)

Source-annotated domains

23–166 (Extracellular); 188–567 (Cytoplasmic)

Source-annotated extracellular intervals

23–166

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
23	166	144	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 6819d0fb0098723a93297e59b510399b63b4ab28cdf32f4ce9966bd646317ad3 Amino-acid sequence for this intervalTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQ

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P37173

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1310899, ECO:0000269|PubMed:25893292}; Single-pass type I membrane protein {ECO:0000269|PubMed:1310899}. Membrane raft {ECO:0000269|PubMed:25893292}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:34568316}.
transmembrane: TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 23..166; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 188..567; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..22; /evidence="ECO:0000269|PubMed:15340161"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: TGF-beta receptor type-2
Protein location: Transmembrane protein
Canonical sequence: P37173 · 567 amino acids
Extracellular region: UniProt annotates extracellular residues 23–166.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in all
Protein specificity: Tissue enhanced
Protein distribution: Detected in many
Immunofluorescence reliability: Enhanced
Protein tissue-specific intensity: intestine: 1,230,588.4
Tissue cell-type enrichment: Heart muscle - Macrophages, Kidney - Endothelial cells, Pancreas - Endothelial cells, Pituitary gland - Endothelial cells, Stomach - Endothelial cells, Testis - Endothelial cells, Thyroid gland - Endothelial cells
Subcellular location: Plasma membrane

Human Protein Atlas: TGFBR2

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

TGFBR2 · ENSG00000163513 · P37173