TNFRSF4

Tumor necrosis factor receptor superfamily member 4. UniProt annotates extracellular residues 29–214.

Sequence and protein regions

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RNA expression by cell type

Percentage of cells with detected TNFRSF4 RNA in the public colon adenocarcinoma cell groups.

Regulatory T cells48.3%

Endothelial cells28.8%

CD4 T cells20.0%

B cells12.0%

Granulocytes11.8%

Dendritic cells9.2%

Natural killer cells6.4%

Macrophages (group B)6.1%

Macrophages (group A)3.7%

Fibroblasts2.9%

CD8 T cells2.5%

Adipocytes2.2%

Tumor cells2.1%

RNA detection · Cancer Surfaceome Atlas, Table S6, row 164. Source study · Measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000186827
UniProt accession: P43489
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 277
Sequence SHA-256: 961acc71fe9b1ba77818a9ff4ffc482d025282f51ac07b592ad4ddeadfc2d60e

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Canonical amino-acid sequence

MCVGARRLGRGPCAALLLLGLGLSTVTGLHCVGDTYPSNDRCCHECRPGNGMVSRCSRSQNTVCRPCGPGFYNDVVSSKPCKPCTWCNLRSGSERKQLCTATQDTVCRCRAGTQPLDSYKPGVDCAPCPPGHFSPGDNQACKPWTNCTLAGKHTLQPASNSSDAICEDRDPPATQPQETQGPPARPITVQPTEAWPRTSQGPSTRPVEVPGGRAVAAILGLGLVLGLLGPLAILLALYLLRRDQRLPPDAHKPPGGGSFRTPIQEEQADAHSTLAKI

Sequence positions 1–277

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–28

Membrane-spanning segments

215–235 (Helical)

Source-annotated domains

29–214 (Extracellular); 236–277 (Cytoplasmic)

Source-annotated extracellular intervals

29–214

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
29	214	186	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 6eba8152a09aec42bf4883842dabf67b898bf0126edd01ac8a65820433dd00b6 Amino-acid sequence for this intervalLHCVGDTYPSNDRCCHECRPGNGMVSRCSRSQNTVCRPCGPGFYNDVVSSKPCKPCTWCNLRSGSERKQLCTATQDTVCRCRAGTQPLDSYKPGVDCAPCPPGHFSPGDNQACKPWTNCTLAGKHTLQPASNSSDAICEDRDPPATQPQETQGPPARPITVQPTEAWPRTSQGPSTRPVEVPGGRA

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P43489

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subcellular_location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
transmembrane: TRANSMEM 215..235; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 29..214; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 236..277; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..28; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Tumor necrosis factor receptor superfamily member 4
Protein location: Transmembrane protein
Canonical sequence: P43489 · 277 amino acids
Extracellular region: UniProt annotates extracellular residues 29–214.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: adipose tissue: 9.6; heart muscle: 10.4; lymphoid tissue: 12.7
Protein specificity: Not detected
Protein distribution: Not detected
Immunohistochemistry reliability: Enhanced
Tissue cell-type enrichment: Minor Salivary Gland - Plasma cells

Human Protein Atlas: TNFRSF4

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

TNFRSF4 · ENSG00000186827 · P43489