Surface AtlasMucinous colon cancer

ABCB1

ATP-dependent translocase ABCB1. UniProt annotates extracellular residues 68–116, 209–215, 317–330, 733–756, 854–854, 958–973.

Sequence and protein regions

Explore the ABCB1 sequence, select annotated regions, and copy a request to continue in Codex.

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RNA expression in tumor samples

Median ABCB1 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples706.4
Other tumor types438 samples573.4
Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000085563
UniProt accession
P08183
Sequence state
available
Canonical sequence
Yes
Length in amino acids
1280
Sequence SHA-256
e104bd0942475592d1b9846250cd047178657b11a0718e3dc71de016002d13f9
View and select the full canonical sequence
Sequence positions 1–1280

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments
45–67: Helical117–137: Helical187–208: Helical216–236: Helical293–316: Helical331–352: Helical712–732: Helical757–777: Helical833–853: Helical855–874: Helical935–957: Helical974–995: Helical
45–67 (Helical); 117–137 (Helical); 187–208 (Helical); 216–236 (Helical); 293–316 (Helical); 331–352 (Helical); 712–732 (Helical); 757–777 (Helical); 833–853 (Helical); 855–874 (Helical); 935–957 (Helical); 974–995 (Helical)
Source-annotated domains
1–44: Cytoplasmic68–116: Extracellular138–186: Cytoplasmic209–215: Extracellular237–292: Cytoplasmic317–330: Extracellular353–711: Cytoplasmic733–756: Extracellular778–832: Cytoplasmic854–854: Extracellular875–934: Cytoplasmic958–973: Extracellular996–1280: Cytoplasmic
1–44 (Cytoplasmic); 68–116 (Extracellular); 138–186 (Cytoplasmic); 209–215 (Extracellular); 237–292 (Cytoplasmic); 317–330 (Extracellular); 353–711 (Cytoplasmic); 733–756 (Extracellular); 778–832 (Cytoplasmic); 854–854 (Extracellular); 875–934 (Cytoplasmic); 958–973 (Extracellular); 996–1280 (Cytoplasmic)
Source-annotated extracellular intervals
68–116209–215317–330733–756854–854958–973
68–116; 209–215; 317–330; 733–756; 854–854; 958–973

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
6811649
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
791a6a61e6b0c938331c11885cd4bed097fb548d4fcee2f545c156b6adceafc5
2092157
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
112c866f8fda3b3ec568f77138e97f34922865791e0e62007ec5d073fafd9a91
31733014
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
d2223b06b7e6b20cad396a5fd41f597e9f5c9aa771a9e26758c49b939e2d1742
73375624
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
08e3501f84bc9dee1e6055560cb290982bc57d8d75dd3ff6e35c6f964d31a923
8548541
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
333e0a1e27815d0ceee55c473fe3dc93d56c63e3bee2b3b4aee8eed6d70191a3
95897316
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
8d37d704b09a5ecf8cdf67885e57286d6c0466d96c579903ed14edd87265b0bd
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

Download source snapshot

Open sequence source
Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
P08183

Download source snapshot (gzip)

subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:35970996}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Apical cell membrane {ECO:0000269|PubMed:28408210, ECO:0000269|PubMed:8898203}. Cytoplasm {ECO:0000269|PubMed:35970996}. Note=ABCB1 localization is influenced by C1orf115 expression levels (plasma membrane versus cytoplasm). Localized to the apical membrane of enterocytes (PubMed:28408210). {ECO:0000269|PubMed:28408210, ECO:0000269|PubMed:35970996}.
transmembrane
TRANSMEM 45..67; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 187..208; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 216..236; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 293..316; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 331..352; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 712..732; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 757..777; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 833..853; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 855..874; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 935..957; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 974..995; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
topological_domain
TOPO_DOM 1..44; /note="Cytoplasmic"; /evidence="ECO:0000250"; TOPO_DOM 68..116; /note="Extracellular"; /evidence="ECO:0000250"; TOPO_DOM 138..186; /note="Cytoplasmic"; /evidence="ECO:0000250"; TOPO_DOM 209..215; /note="Extracellular"; /evidence="ECO:0000250"; TOPO_DOM 237..292; /note="Cytoplasmic"; /evidence="ECO:0000250"; TOPO_DOM 317..330; /note="Extracellular"; /evidence="ECO:0000250"; TOPO_DOM 353..711; /note="Cytoplasmic"; /evidence="ECO:0000250"; TOPO_DOM 733..756; /note="Extracellular"; /evidence="ECO:0000250"; TOPO_DOM 778..832; /note="Cytoplasmic"; /evidence="ECO:0000250"; TOPO_DOM 854; /note="Extracellular"; /evidence="ECO:0000250"; TOPO_DOM 875..934; /note="Cytoplasmic"; /evidence="ECO:0000250"; TOPO_DOM 958..973; /note="Extracellular"; /evidence="ECO:0000250"; TOPO_DOM 996..1280; /note="Cytoplasmic"; /evidence="ECO:0000250"
signal_peptide
Not recorded
lipidation
Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
ATP-dependent translocase ABCB1
Protein location
Transmembrane protein
Canonical sequence
P08183 · 1,280 amino acids
Extracellular region
UniProt annotates extracellular residues 68–116, 209–215, 317–330, 733–756, 854–854, 958–973.

Expression in normal tissues

RNA specificity
Tissue enhanced
RNA distribution
Detected in many
RNA tissue-specific nTPM
adrenal gland: 96.1; intestine: 66.6
Protein specificity
Tissue enhanced
Protein distribution
Detected in many
Immunohistochemistry reliability
Enhanced
Immunofluorescence reliability
Supported
Protein tissue-specific intensity
intestine: 3,491,920.0
Tissue cell-type enrichment
Adrenal gland - Adrenal cortex cells, Prostate - Endothelial cells, Spleen - NK-cells (Spleen)
Subcellular location
Plasma membrane

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

ABCB1 · ENSG00000085563 · P08183

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