Surface AtlasMucinous colon cancer

ABCG2

Broad substrate specificity ATP-binding cassette transporter ABCG2. UniProt annotates extracellular residues 417–428, 499–506, 557–630.

Sequence and protein regions

Explore the ABCG2 sequence, select annotated regions, and copy a request to continue in Codex.

Open this view

RNA expression in tumor samples

Median ABCG2 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples47.9
Other tumor types438 samples24.2
Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

Choose a protein region, search amino-acid letters, or inspect a recorded binding site.

Loading sequence…

Open the sequence explorer
Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000118777
UniProt accession
Q9UNQ0
Sequence state
available
Canonical sequence
Yes
Length in amino acids
655
Sequence SHA-256
30326c2220d9e1ae10af82deb915b0251b33cdf56035a050ece15cd2fedfb894
View and select the full canonical sequence
Sequence positions 1–655

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments
396–416: Helical429–449: Helical478–498: Helical507–527: Helical536–556: Helical631–651: Helical
396–416 (Helical); 429–449 (Helical); 478–498 (Helical); 507–527 (Helical); 536–556 (Helical); 631–651 (Helical)
Source-annotated domains
1–395: Cytoplasmic417–428: Extracellular450–477: Cytoplasmic499–506: Extracellular528–535: Cytoplasmic557–630: Extracellular652–655: Cytoplasmic
1–395 (Cytoplasmic); 417–428 (Extracellular); 450–477 (Cytoplasmic); 499–506 (Extracellular); 528–535 (Cytoplasmic); 557–630 (Extracellular); 652–655 (Cytoplasmic)
Source-annotated extracellular intervals
417–428499–506557–630
417–428; 499–506; 557–630

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
41742812
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
3e3090ba67b408660981ef8bf77f93fab87b5dd0a8f00f56c5cad5782a67e660
4995068
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
5a2439f746d6a670aa109b5b5ea24a1c100d29491c50709a36706db001dc7882
55763074
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
32fbbebd81ccbc08096195a556214c9a0dfe0edfb88ef20ffab14c69b018be1b
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

Download source snapshot

Open sequence source
Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
Q9UNQ0

Download source snapshot (gzip)

subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15001581, ECO:0000269|PubMed:15769853, ECO:0000269|PubMed:15807535, ECO:0000269|PubMed:18056989, ECO:0000269|PubMed:31003562, ECO:0000269|PubMed:31254042}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:19506252}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:23189181}; Multi-pass membrane protein {ECO:0000255}. Note=Enriched in membrane lipid rafts. {ECO:0000269|PubMed:28623970}.
transmembrane
TRANSMEM 396..416; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 429..449; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 478..498; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 507..527; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 536..556; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 631..651; /note="Helical"; /evidence="ECO:0000255"
topological_domain
TOPO_DOM 1..395; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 417..428; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 450..477; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 499..506; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 528..535; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 557..630; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 652..655; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide
Not recorded
lipidation
Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
Broad substrate specificity ATP-binding cassette transporter ABCG2
Protein location
Transmembrane protein
Canonical sequence
Q9UNQ0 · 655 amino acids
Extracellular region
UniProt annotates extracellular residues 417–428, 499–506, 557–630.

Expression in normal tissues

RNA specificity
Tissue enhanced
RNA distribution
Detected in many
RNA tissue-specific nTPM
intestine: 83.2
Protein specificity
Tissue enriched
Protein distribution
Detected in many
Immunohistochemistry reliability
Enhanced
Immunofluorescence reliability
Supported
Protein tissue-specific intensity
intestine: 3,450,854.1
Tissue cell-type enrichment
Liver - Hepatocytes
Subcellular location
Plasma membrane

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

ABCG2 · ENSG00000118777 · Q9UNQ0

Search the report