ACE2

Angiotensin-converting enzyme 2. UniProt annotates extracellular residues 18–740.

Sequence and protein regions

Explore the ACE2 sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median ACE2 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples298.6

Other tumor types438 samples945.2

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000130234
UniProt accession: Q9BYF1
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 805
Sequence SHA-256: 87630d0ccd9e8de7f77cb47c03fd56d745d66fbdceb8a2149b3518b04d71e1ea

View and select the full canonical sequence

Canonical amino-acid sequence

MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLNDNSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGENPYASIDISKGENNPGFQNTDDVQTSF

Sequence positions 1–805

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–17

Membrane-spanning segments

741–761 (Helical)

Source-annotated domains

18–740 (Extracellular); 762–805 (Cytoplasmic)

Source-annotated extracellular intervals

18–740

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
18	740	723	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 1398ee1b8a90192ba70ec0a5025890bd6b61bbd6110a638c5eea9fe620b02c0b Amino-acid sequence for this intervalQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLNDNSLEFLGIQPTLGPPNQPPVS

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q9BYF1

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subcellular_location: SUBCELLULAR LOCATION: [Processed angiotensin-converting enzyme 2]: Secreted {ECO:0000269|PubMed:15983030, ECO:0000269|PubMed:33713620}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18424768}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8R0I0}. Cell projection, cilium {ECO:0000269|PubMed:33432184}. Apical cell membrane {ECO:0000269|PubMed:33432184}. Note=Detected in both cell membrane and cytoplasm in neurons. {ECO:0000250|UniProtKB:Q8R0I0}.; SUBCELLULAR LOCATION: [Isoform 2]: Apical cell membrane {ECO:0000269|PubMed:33432184}.
transmembrane: TRANSMEM 741..761; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01354"
topological_domain: TOPO_DOM 18..740; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 762..805; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..17; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Angiotensin-converting enzyme 2
Protein location: Transmembrane protein
Canonical sequence: Q9BYF1 · 805 amino acids
Extracellular region: UniProt annotates extracellular residues 18–740.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: gallbladder: 62.3; intestine: 230.5; kidney: 82.4
Protein specificity: Group enriched
Protein distribution: Detected in some
Immunohistochemistry reliability: Enhanced
Protein tissue-specific intensity: intestine: 6,364,185.6; kidney: 9,342,506.8; pancreas: 19,350,961.8
Tissue cell-type enrichment: Kidney - Proximal tubular cells, Liver - Hepatocytes, Minor Salivary Gland - Minor salivary glandular cells

Human Protein Atlas: ACE2

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

ACE2 · ENSG00000130234 · Q9BYF1