ALPP

Alkaline phosphatase, placental type. An extracellular span at residues 23–505 is derived from the signal peptide and GPI attachment annotation.

Sequence and protein regions

Explore the ALPP sequence, select annotated regions, and copy a request to continue in Codex.

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RNA expression in tumor samples

Median ALPP RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples5.3

Other tumor types438 samples2.0

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000163283
UniProt accession: P05187
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 535
Sequence SHA-256: 72457bd3e469b5da79ef671c8cecc272c88c727382f4cdaae3eea77a773396db

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Canonical amino-acid sequence

MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP

Sequence positions 1–535

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–22

Membrane-spanning segments

513–529 (Helical)

Lipid attachment sites

506–506 (GPI-anchor amidated aspartate)

Derived extracellular interval

23–505

The extracellular interval is derived from the signal peptide and GPI attachment site. It is a proposed construct interval.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
23	505	483	Sequence and source Basis interval-after-reviewed-signal-before-reviewed-gpi-anchor Evidence class topology-derived-construct-hypothesis Sequence SHA-256 e74ef883bfb59cdcdff1e8a908ac488d6dc2b6366c2a6a6cab228089d070f937 Amino-acid sequence for this intervalIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAGTT

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P05187

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:1730777, ECO:0000269|PubMed:2153284}.
transmembrane: TRANSMEM 513..529; /note="Helical"
topological_domain: Not recorded
signal_peptide: SIGNAL 1..22; /evidence="ECO:0000269|PubMed:6651840"
lipidation: LIPID 506; /note="GPI-anchor amidated aspartate"; /evidence="ECO:0000269|PubMed:2153284"

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Alkaline phosphatase, placental type
Protein location: GPI-anchored membrane protein
Canonical sequence: P05187 · 535 amino acids
Extracellular region: An extracellular span at residues 23–505 is derived from the signal peptide and GPI attachment annotation.

Expression in normal tissues

RNA specificity: Group enriched
RNA distribution: Detected in some
RNA tissue-specific nTPM: cervix: 16.7; placenta: 32.6
Protein specificity: Not detected
Protein distribution: Not detected
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Approved
Subcellular location: Plasma membrane

Human Protein Atlas: ALPP

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

ALPP · ENSG00000163283 · P05187