Surface AtlasMucinous colon cancer

ANO7

Anoctamin-7. UniProt annotates extracellular residues 377–420, 521–550, 610–714, 785–843.

Sequence and protein regions

Explore the ANO7 sequence, select annotated regions, and copy a request to continue in Codex.

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RNA expression in tumor samples

Median ANO7 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples188.4
Other tumor types438 samples50.9
Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000146205
UniProt accession
Q6IWH7
Sequence state
available
Canonical sequence
Yes
Length in amino acids
933
Sequence SHA-256
e8316f260f3fa1cd475aa83846d041ba6f3541efd51176f4ddd70340d38bd074
View and select the full canonical sequence
Sequence positions 1–933

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments
356–376: Helical421–441: Helical500–520: Helical551–571: Helical589–609: Helical715–735: Helical764–784: Helical844–864: Helical
356–376 (Helical); 421–441 (Helical); 500–520 (Helical); 551–571 (Helical); 589–609 (Helical); 715–735 (Helical); 764–784 (Helical); 844–864 (Helical)
Source-annotated domains
1–355: Cytoplasmic377–420: Extracellular442–499: Cytoplasmic521–550: Extracellular572–588: Cytoplasmic610–714: Extracellular736–763: Cytoplasmic785–843: Extracellular865–933: Cytoplasmic
1–355 (Cytoplasmic); 377–420 (Extracellular); 442–499 (Cytoplasmic); 521–550 (Extracellular); 572–588 (Cytoplasmic); 610–714 (Extracellular); 736–763 (Cytoplasmic); 785–843 (Extracellular); 865–933 (Cytoplasmic)
Source-annotated extracellular intervals
377–420521–550610–714785–843
377–420; 521–550; 610–714; 785–843

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
37742044
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
c2bbe1cc5d74b14421c53e21cdc774ae34b94264b7aea0e6d5894d55bd8d257e
52155030
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
3daf6a9a2fb7d82a61f132097deadfbba19bced2fa0714615cb417443d2d95b0
610714105
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
cbe2a93bb712ed105bb47b31b7b86448c13e1812f6da88538bfc0e4a2450bb3c
78584359
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
80ffc1b1916f3bf46b9284400a9e81af024c7ba069190ee96a14d5356fb1e85e
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

Download source snapshot

Open sequence source
Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
Q6IWH7

Download source snapshot (gzip)

subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:14981236, ECO:0000269|PubMed:17308099, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}; Multi-pass membrane protein {ECO:0000255}. Cell junction {ECO:0000269|PubMed:17308099}. Endoplasmic reticulum {ECO:0000269|PubMed:22075693}. Note=Concentrates at sites of cell-cell contact (PubMed:17308099). Shows an intracellular localization according to PubMed:22075693 and PubMed:20056604. {ECO:0000269|PubMed:17308099, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22075693}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:14981236}.
transmembrane
TRANSMEM 356..376; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 421..441; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 500..520; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 551..571; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 589..609; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 715..735; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 764..784; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 844..864; /note="Helical"; /evidence="ECO:0000255"
topological_domain
TOPO_DOM 1..355; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 377..420; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 442..499; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 521..550; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 572..588; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 610..714; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 736..763; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 785..843; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 865..933; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide
Not recorded
lipidation
Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
Anoctamin-7
Protein location
Transmembrane protein
Canonical sequence
Q6IWH7 · 933 amino acids
Extracellular region
UniProt annotates extracellular residues 377–420, 521–550, 610–714, 785–843.

Expression in normal tissues

RNA specificity
Group enriched
RNA distribution
Detected in some
RNA tissue-specific nTPM
intestine: 18.0; prostate: 66.6; stomach 1: 26.9
Protein specificity
Not detected
Protein distribution
Not detected
Immunohistochemistry reliability
Enhanced
Tissue cell-type enrichment
Colon - Colon enterocytes, Minor Salivary Gland - Minor salivary glandular cells, Prostate - Prostate glandular cells, Stomach - Gastric mucous cells

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

ANO7 · ENSG00000146205 · Q6IWH7

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