BMPR1A

Bone morphogenetic protein receptor type-1A. UniProt annotates extracellular residues 24–152.

Sequence and protein regions

Explore the BMPR1A sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median BMPR1A RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples388.3

Other tumor types438 samples476.6

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000107779
UniProt accession: P36894
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 532
Sequence SHA-256: 2d43213963de67d768d71ee3edbd337e1d66e34f88a5ef5ebdcbee782cb3980d

View and select the full canonical sequence

Canonical amino-acid sequence

MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI

Sequence positions 1–532

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–23

Membrane-spanning segments

153–176 (Helical)

Source-annotated domains

24–152 (Extracellular); 177–532 (Cytoplasmic)

Source-annotated extracellular intervals

24–152

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
24	152	129	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 21ee8b4725d8e4ce746ed60243bd241d36f7432ebce4c377d40ae6127521dc1c Amino-acid sequence for this intervalQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIR

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P36894

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19726563}; Single-pass type I membrane protein {ECO:0000255}. Cell surface {ECO:0000250|UniProtKB:P36895}.
transmembrane: TRANSMEM 153..176; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 24..152; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 177..532; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..23; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Bone morphogenetic protein receptor type-1A
Protein location: Transmembrane protein
Canonical sequence: P36894 · 532 amino acids
Extracellular region: UniProt annotates extracellular residues 24–152.

Expression in normal tissues

RNA specificity: Low tissue specificity
RNA distribution: Detected in many
Protein specificity: Tissue enriched
Protein distribution: Detected in single
Immunohistochemistry reliability: Approved
Immunofluorescence reliability: Approved
Protein tissue-specific intensity: cerebral cortex: 29,543.5
Tissue cell-type enrichment: Prostate - Smooth muscle cells, Thyroid gland - Thyroid glandular cells
Subcellular location: Cytosol

Human Protein Atlas: BMPR1A

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

BMPR1A · ENSG00000107779 · P36894