CDH3

Cadherin-3. UniProt annotates extracellular residues 108–654.

Sequence and protein regions

Explore the CDH3 sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median CDH3 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples1,594.4

Other tumor types438 samples1,830.8

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000062038
UniProt accession: P22223
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 829
Sequence SHA-256: 2469935445ed65fca853e5f1237c7280a339fe2cc5d90f6b0f1ca319d21dff48

View and select the full canonical sequence

Canonical amino-acid sequence

MGLPRGPLASLLLLQVCWLQCAASEPCRAVFREAEVTLEAGGAEQEPGQALGKVFMGCPGQEPALFSTDNDDFTVRNGETVQERRSLKERNPLKIFPSKRILRRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTGEPVCVYTAEDPDKENQKISYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQFVRNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGPVPEPRQITICNQSPVRQVLNITDKDLSPHTSPFQAQLTDDSDIYWTAEVNEEGDTVVLSLKKFLKQDTYDVHLSLSDHGNKEQLTVIRATVCDCHGHVETCPGPWKGGFILPVLGAVLALLFLLLVLLLLVRKKRKIKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHRGLEARPEVVLRNDVAPTIIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDTLLVFDYEGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYGGGEDD

Sequence positions 1–829

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–24

Membrane-spanning segments

655–677 (Helical)

Source-annotated domains

108–654 (Extracellular); 678–829 (Cytoplasmic)

Source-annotated extracellular intervals

108–654

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
108	654	547	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 3bf878ac541e9c632a2fb477479c7ea1bb92cab5d89777e9533f45d0496d1361 Amino-acid sequence for this intervalDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGDGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPENAVGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTGEPVCVYTAEDPDKENQKISYRILRDPAGWLAMDPDSGQVTAVGTLDREDEQFVRNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGPVPEPRQITICNQSPVRQVLNITDKDLSPHTSPFQAQLTDDSDIYWTAEVNEEGDTVVLSLKKFLKQDTYDVHLSLSDHGNKEQLTVIRATVCDCHGHVETCPGPWKGG

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P22223

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
transmembrane: TRANSMEM 655..677; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 108..654; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 678..829; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..24; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Cadherin-3
Protein location: Transmembrane protein
Canonical sequence: P22223 · 829 amino acids
Extracellular region: UniProt annotates extracellular residues 108–654.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: choroid plexus: 51.8; ovary: 32.3
Protein specificity: Tissue enriched
Protein distribution: Detected in some
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Supported
Protein tissue-specific intensity: fallopian tube: 6,986,606.4
Tissue cell-type enrichment: Adipose visceral - Mesothelial cells, Spleen - Fibroblasts_1
Subcellular location: Plasma membrane, Cell Junctions

Human Protein Atlas: CDH3

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

CDH3 · ENSG00000062038 · P22223