DLL3

Delta-like protein 3. UniProt annotates extracellular residues 27–492.

Sequence and protein regions

Explore the DLL3 sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median DLL3 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples3.3

Other tumor types438 samples3.6

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000090932
UniProt accession: Q9NYJ7
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 618
Sequence SHA-256: 08655e45c9c70122a1320e3ba4b74aa9d81f6e2598e67d546a928ae5498e801e

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Canonical amino-acid sequence

MVSPRMSGLLSQTVILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSARLPCRLFFRVCLKPGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPDGLLQVPFRDAWPGTFSFIIETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALPAAPPGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRRGHSQDAGSRLLAGTPEPSVHALPDALNNLRTQEGSGDGPSSSVDWNRPEDVDPQGIYVISAPSIYAREVATPLFPPLHTGRAGQRQHLLFPYPSSILSVK

Sequence positions 1–618

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–26

Membrane-spanning segments

493–513 (Helical)

Source-annotated domains

27–492 (Extracellular); 514–618 (Cytoplasmic)

Source-annotated extracellular intervals

27–492

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
27	492	466	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 42d8aca55d42ea0481546c750785ba5962abb79b9be60cda4de0073a4c749ee0 Amino-acid sequence for this intervalAGVFELQIHSFGPGPGPGAPRSPCSARLPCRLFFRVCLKPGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPDGLLQVPFRDAWPGTFSFIIETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALPAAPPGLRPGDPQRYL

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q9NYJ7

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subcellular_location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
transmembrane: TRANSMEM 493..513; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 27..492; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 514..618; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..26; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)