Surface AtlasESR1
Estrogen receptor. The canonical sequence contains 595 amino acids.
Sequence and protein regions
Explore the ESR1 sequence, select annotated regions, and copy a request to continue in Codex.
Open this viewRNA expression in tumor samples
Median ESR1 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.
Mucinous tumors37 samples8.9
Other tumor types438 samples5.7
Sequence & binding sites
Choose a protein region, search amino-acid letters, or inspect a recorded binding site.
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Open the sequence explorerSequence annotations and source records
Canonical sequence and topology
- Target ID
- T-ENSG00000091831
- UniProt accession
- P03372
- Sequence state
- available
- Canonical sequence
- Yes
- Length in amino acids
- 595
- Sequence SHA-256
- 59afaf3c8774c9cec06a003e9fa0d1fb1da47637c45ea570236e0ca79b5a0a44
View and select the full canonical sequence
Gray shows the full canonical sequence. Colored spans mark the listed intervals.
Lipid attachment sites
447–447 (S-palmitoyl cysteine)
This collection has no explicit extracellular interval for this protein.
Sequence and topology sources
- Source role
- canonical-sequence
- Source
- alphafold-db-canonical-uniprot-field
- Extracted field
- uniprotSequence
- Source row accession
- Not recorded
- Source role
- reviewed-topology
- Source
- UniProt reviewed human surface-field snapshot
- Extracted field
- Not recorded
- Source row accession
- P03372
Download source snapshot (gzip)
- subcellular_location
- SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:12682286, ECO:0000269|PubMed:20074560}. Cytoplasm {ECO:0000269|PubMed:12682286, ECO:0000269|PubMed:24498420}. Cell membrane {ECO:0000269|PubMed:12682286}; Peripheral membrane protein {ECO:0000269|PubMed:12682286}; Cytoplasmic side {ECO:0000269|PubMed:12682286}. Note=A minor fraction is associated with the inner membrane.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Single-pass type I membrane protein. Note=Associated with the inner membrane via palmitoylation (Probable). At least a subset exists as a transmembrane protein with a N-terminal extracellular domain. {ECO:0000305}.; SUBCELLULAR LOCATION: Nucleus. Golgi apparatus. Cell membrane. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.
- transmembrane
- Not recorded
- topological_domain
- Not recorded
- signal_peptide
- Not recorded
- lipidation
- LIPID 447; /note="S-palmitoyl cysteine"; /evidence="ECO:0000250"
Protein identity and location
- Protein
- Estrogen receptor
- Protein location
- Nucleus and cytoplasm; cytoplasmic membrane face in isoform 1
- Canonical sequence
- P03372 · 595 amino acids
Expression in normal tissues
- RNA specificity
- Tissue enhanced
- RNA distribution
- Detected in many
- RNA tissue-specific nTPM
- cervix: 80.7; endometrium 1: 103.7; fallopian tube: 61.1
- Protein specificity
- Tissue enriched
- Protein distribution
- Detected in single
- Immunohistochemistry reliability
- Enhanced
- Immunofluorescence reliability
- Approved
- Protein tissue-specific intensity
- fallopian tube: 247,248.4
- Tissue cell-type enrichment
- Breast - Breast glandular cells, Kidney - Fibroblasts, Liver - Hepatocytes, Pituitary gland - Gonadotropes, Testis - Early spermatids, Testis - Late spermatids, Thyroid gland - Fibroblasts
- Subcellular location
- Vesicles
Sources and downloads
ESR1 · ENSG00000091831 · P03372