Surface AtlasFOLR1
Folate receptor alpha. An extracellular span at residues 25–233 is derived from the signal peptide and GPI attachment annotation.
Sequence and protein regions
Explore the FOLR1 sequence, select annotated regions, and copy a request to continue in Codex.
Open this viewRNA expression in tumor samples
Median FOLR1 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.
Mucinous tumors37 samples17.0
Other tumor types438 samples22.5
Sequence & binding sites
Choose a protein region, search amino-acid letters, or inspect a recorded binding site.
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Open the sequence explorerSequence annotations and source records
Canonical sequence and topology
- Target ID
- T-ENSG00000110195
- UniProt accession
- P15328
- Sequence state
- available
- Canonical sequence
- Yes
- Length in amino acids
- 257
- Sequence SHA-256
- 32c0a619bf0594c065d065d7e221ae2f11c85a62b9d2c5337b44f3930ba58400
View and select the full canonical sequence
Gray shows the full canonical sequence. Colored spans mark the listed intervals.
Signal peptide
1–24
Lipid attachment sites
234–234 (GPI-anchor amidated serine)
Derived extracellular interval
25–233
The extracellular interval is derived from the signal peptide and GPI attachment site. It is a proposed construct interval.
| Start | End | Length | Sequence and source |
|---|---|---|---|
| 25 | 233 | 209 | Sequence and source
|
Sequence and topology sources
- Source role
- canonical-sequence
- Source
- alphafold-db-canonical-uniprot-field
- Extracted field
- uniprotSequence
- Source row accession
- Not recorded
- Source role
- reviewed-topology
- Source
- UniProt reviewed human surface-field snapshot
- Extracted field
- Not recorded
- Source row accession
- P15328
Download source snapshot (gzip)
- subcellular_location
- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Apical cell membrane {ECO:0000269|PubMed:10787414}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Basolateral cell membrane {ECO:0000269|PubMed:10787414}; Lipid-anchor, GPI-like-anchor {ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066}. Secreted {ECO:0000305|PubMed:3476960}. Cytoplasmic vesicle {ECO:0000269|PubMed:8567728}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:8567728}. Endosome {ECO:0000269|PubMed:8567728}. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane. {ECO:0000269|PubMed:8567728}.
- transmembrane
- Not recorded
- topological_domain
- Not recorded
- signal_peptide
- SIGNAL 1..24; /evidence="ECO:0000255"
- lipidation
- LIPID 234; /note="GPI-anchor amidated serine"; /evidence="ECO:0000269|PubMed:17566972, ECO:0000269|PubMed:7578066"
Protein identity and location
- Protein
- Folate receptor alpha
- Protein location
- GPI-anchored membrane protein
- Canonical sequence
- P15328 · 257 amino acids
- Extracellular region
- An extracellular span at residues 25–233 is derived from the signal peptide and GPI attachment annotation.
Expression in normal tissues
- RNA specificity
- Tissue enriched
- RNA distribution
- Detected in many
- RNA tissue-specific nTPM
- choroid plexus: 2,860.9
- Protein specificity
- Group enriched
- Protein distribution
- Detected in some
- Protein tissue-specific intensity
- fallopian tube: 14,412,848.9; kidney: 8,726,954.0; lung: 19,514,046.3
- Tissue cell-type enrichment
- Kidney - Proximal tubular cells, Lung - Alveolar cells type 1, Minor Salivary Gland - Minor salivary glandular cells, Pituitary gland - Undifferentiated cells (Pituitary gland), Skin - Eccrine sweat gland cells, Thyroid gland - Thyroid glandular cells
Sources and downloads
FOLR1 · ENSG00000110195 · P15328