FUT3

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3. The canonical sequence contains 361 amino acids.

Sequence and protein regions

Explore the FUT3 sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median FUT3 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples3,644.3

Other tumor types438 samples2,751.3

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

Choose a protein region, search amino-acid letters, or inspect a recorded binding site.

Loading sequence…

Open the sequence explorer

Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000171124
UniProt accession: P21217
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 361
Sequence SHA-256: b61c11011f05f674924fd36208448ef5cb1b06449508241cff49916b813ecf0b

View and select the full canonical sequence

Canonical amino-acid sequence

MDPLGAAKPQWPWRRCLAALLFQLLVAVCFFSYLRVSRDDATGSPRAPSGSSRQDTTPTRPTLLILLRTWPFHIPVALSRCSEMVPGTADCHITADRKVYPQADMVIVHHWDIMSNPKSRLPPSPRPQGQRWIWFNLEPPPNCQHLEALDRYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWKPDSARVRYYQSLQAHLKVDVYGRSHKPLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALDFCKACWKLQQESRYQTVRSIAAWFT

Sequence positions 1–361

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments

16–34 (Helical; Signal-anchor for type II membrane protein)

Source-annotated domains

1–15 (Cytoplasmic); 35–361 (Lumenal)

This collection has no explicit extracellular interval for this protein.

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

Download source snapshot

Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P21217

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein {ECO:0000269|PubMed:1977660}. Note=Membrane-bound form in trans cisternae of Golgi.
transmembrane: TRANSMEM 16..34; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255, ECO:0000269|PubMed:1977660"
topological_domain: TOPO_DOM 1..15; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 35..361; /note="Lumenal"; /evidence="ECO:0000255"
signal_peptide: Not recorded
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3
Protein location: Transmembrane protein
Canonical sequence: P21217 · 361 amino acids

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: esophagus: 150.8; intestine: 67.6; retina: 76.2; salivary gland: 79.3
Protein specificity: Tissue enriched
Protein distribution: Detected in single
Immunohistochemistry reliability: Supported
Protein tissue-specific intensity: intestine: 19,006,047.1
Tissue cell-type enrichment: Breast - Breast glandular cells, Colon - Colon enterocytes, Kidney - Proximal tubular cells, Kidney - Proximal tubular cells, Lung - Alveolar cells type 2, Prostate - Urothelial cells, Stomach - Gastric mucous cells

Human Protein Atlas: FUT3

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

FUT3 · ENSG00000171124 · P21217