GPC3

Glypican-3. An extracellular span at residues 25–553 is derived from the signal peptide and GPI attachment annotation.

Sequence and protein regions

Explore the GPC3 sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median GPC3 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples40.9

Other tumor types438 samples32.3

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000147257
UniProt accession: P51654
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 580
Sequence SHA-256: 77dfca719964bc76f8f4a345c1fa314a8b55845c770a272f9b3e2e81f348df23

View and select the full canonical sequence

Canonical amino-acid sequence

MAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYTQLMNPGLPDSALDINECLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNAGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVAHVEHEETLSSRRRELIQKLKSFISFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSMPKGRVLDKNLDEEGFESGDCGDDEDECIGGSGDGMIKVKNQLRFLAELAYDLDVDDAPGNSQQATPKDNEISTFHNLGNVHSPLKLLTSMAISVVCFFFLVH

Sequence positions 1–580

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–24

Lipid attachment sites

554–554 (GPI-anchor amidated asparagine)

Derived extracellular interval

25–553

The extracellular interval is derived from the signal peptide and GPI attachment site. It is a proposed construct interval.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
25	553	529	Sequence and source Basis interval-after-reviewed-signal-before-reviewed-gpi-anchor Evidence class topology-derived-construct-hypothesis Sequence SHA-256 730502db3c0dab6a2b8e5df80e6b1956101ba71ed1d156e606f51f55d8c886e7 Amino-acid sequence for this intervalQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYTQLMNPGLPDSALDINECLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNAGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVAHVEHEETLSSRRRELIQKLKSFISFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSMPKGRVLDKNLDEEGFESGDCGDDEDECIGGSGDGMIKVKNQLRFLAELAYDLDVDDAPGNSQQATPKDNEISTFH

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P51654

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14610063}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P13265}; Extracellular side {ECO:0000250|UniProtKB:P13265}.
transmembrane: Not recorded
topological_domain: Not recorded
signal_peptide: SIGNAL 1..24; /evidence="ECO:0000269|PubMed:29345911"
lipidation: LIPID 554; /note="GPI-anchor amidated asparagine"; /evidence="ECO:0000255"

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Glypican-3
Protein location: GPI-anchored membrane protein
Canonical sequence: P51654 · 580 amino acids
Extracellular region: An extracellular span at residues 25–553 is derived from the signal peptide and GPI attachment annotation.

Expression in normal tissues

RNA specificity: Tissue enriched
RNA distribution: Detected in many
RNA tissue-specific nTPM: placenta: 669.8
Protein specificity: Not detected
Protein distribution: Not detected
Immunofluorescence reliability: Supported
Tissue cell-type enrichment: Adrenal gland - Fibroblasts, Kidney - Fibroblasts, Lung - Fibroblasts_1, Minor Salivary Gland - Fibroblasts, Pancreas - Fibroblasts, Spleen - Smooth muscle cells, Thyroid gland - Fibroblasts
Subcellular location: Plasma membrane

Human Protein Atlas: GPC3

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

GPC3 · ENSG00000147257 · P51654