Surface AtlasGPER1
G protein-coupled estrogen receptor 1. UniProt annotates extracellular residues 1–62, 121–132, 195–220, 281–306.
Sequence and protein regions
Explore the GPER1 sequence, select annotated regions, and copy a request to continue in Codex.
Open this viewRNA expression in tumor samples
Median GPER1 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.
Mucinous tumors37 samples39.5
Other tumor types438 samples31.5
Sequence & binding sites
Choose a protein region, search amino-acid letters, or inspect a recorded binding site.
Loading sequence…
Open the sequence explorerSequence annotations and source records
Canonical sequence and topology
- Target ID
- T-ENSG00000164850
- UniProt accession
- Q99527
- Sequence state
- available
- Canonical sequence
- Yes
- Length in amino acids
- 375
- Sequence SHA-256
- 5e99a0fa68e32001c51058e911d823bca3daec4d518d720b65ecd89e44fd7f96
View and select the full canonical sequence
Gray shows the full canonical sequence. Colored spans mark the listed intervals.
Membrane-spanning segments
63–84 (Helical; Name=1); 97–120 (Helical; Name=2); 133–153 (Helical; Name=3); 176–194 (Helical; Name=4); 221–236 (Helical; Name=5); 260–280 (Helical; Name=6); 307–327 (Helical; Name=7)
Source-annotated domains
1–62 (Extracellular); 85–96 (Cytoplasmic); 121–132 (Extracellular); 154–175 (Cytoplasmic); 195–220 (Extracellular); 237–259 (Cytoplasmic); 281–306 (Extracellular); 328–375 (Cytoplasmic)
Source-annotated extracellular intervals
1–62; 121–132; 195–220; 281–306
UniProt annotates the following extracellular intervals.
| Start | End | Length | Sequence and source |
|---|---|---|---|
| 1 | 62 | 62 | Sequence and source
|
| 121 | 132 | 12 | Sequence and source
|
| 195 | 220 | 26 | Sequence and source
|
| 281 | 306 | 26 | Sequence and source
|
Sequence and topology sources
- Source role
- canonical-sequence
- Source
- alphafold-db-canonical-uniprot-field
- Extracted field
- uniprotSequence
- Source row accession
- Not recorded
- Source role
- reviewed-topology
- Source
- UniProt reviewed human surface-field snapshot
- Extracted field
- Not recorded
- Source row accession
- Q99527
Download source snapshot (gzip)
- subcellular_location
- SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18566127}; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Postsynaptic density {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalized with BSN to the active zone of presynaptic density. Colocalized with DLG4/PSD95 and neurabin-2 PPP1R9B in neuronal synaptosomes (By similarity). Endocytosed in a agonist- and arrestin-independent manner. Colocalized with RAMP3 and clathrin-coated pits at the plasma membrane. Colocalized with transferrin receptor at the plasma membrane and perinuclear region. Accumulated and colocalized with RAB11 proteins in recycling endosomes and trans-Golgi network (TGN), but does neither recycle back to the cell surface nor traffics to late endosome or lysosome. Colocalized with calnexin in the endoplasmic reticulum. Traffics to intracellular sites via cytokeratin intermediate filaments like KRT7 and KRT8 after constitutive endocytosis in epithelial cells. Colocalized with EGFR in the nucleus of agonist-induced cancer-associated fibroblasts (CAF). {ECO:0000250}.
- transmembrane
- TRANSMEM 63..84; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 97..120; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 133..153; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 176..194; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 221..236; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 307..327; /note="Helical; Name=7"; /evidence="ECO:0000255"
- topological_domain
- TOPO_DOM 1..62; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 85..96; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 121..132; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 154..175; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 195..220; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 237..259; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 281..306; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 328..375; /note="Cytoplasmic"; /evidence="ECO:0000255"
- signal_peptide
- Not recorded
- lipidation
- Not recorded
Protein identity and location
- Protein
- G protein-coupled estrogen receptor 1
- Protein location
- Transmembrane protein
- Canonical sequence
- Q99527 · 375 amino acids
- Extracellular region
- UniProt annotates extracellular residues 1–62, 121–132, 195–220, 281–306.
Expression in normal tissues
- RNA specificity
- Tissue enhanced
- RNA distribution
- Detected in many
- RNA tissue-specific nTPM
- stomach 1: 40.9
- Protein specificity
- Not detected
- Protein distribution
- Not detected
- Immunohistochemistry reliability
- Approved
- Immunofluorescence reliability
- Supported
- Tissue cell-type enrichment
- Liver - Hepatocytes, Stomach - Chief cells
- Subcellular location
- Nucleoli
Sources and downloads
GPER1 · ENSG00000164850 · Q99527