Surface AtlasMucinous colon cancer

GPR12

G protein-coupled receptor 12. UniProt annotates extracellular residues 1–48, 104–113, 177–192, 275–280.

Sequence and protein regions

Explore the GPR12 sequence, select annotated regions, and copy a request to continue in Codex.

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RNA expression in tumor samples

Median GPR12 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors23 samples0.0
Other tumor types258 samples0.0
Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000132975
UniProt accession
P47775
Sequence state
available
Canonical sequence
Yes
Length in amino acids
334
Sequence SHA-256
b8ba9acf2458ef97435d600036ced98e3e26853ce1255c0a90f25885c2804707
View and select the full canonical sequence
Sequence positions 1–334

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments
49–71: Helical; Name=178–103: Helical; Name=2114–136: Helical; Name=3154–176: Helical; Name=4193–217: Helical; Name=5252–274: Helical; Name=6281–303: Helical; Name=7
49–71 (Helical; Name=1); 78–103 (Helical; Name=2); 114–136 (Helical; Name=3); 154–176 (Helical; Name=4); 193–217 (Helical; Name=5); 252–274 (Helical; Name=6); 281–303 (Helical; Name=7)
Source-annotated domains
1–48: Extracellular72–77: Cytoplasmic104–113: Extracellular137–153: Cytoplasmic177–192: Extracellular218–251: Cytoplasmic275–280: Extracellular304–334: Cytoplasmic
1–48 (Extracellular); 72–77 (Cytoplasmic); 104–113 (Extracellular); 137–153 (Cytoplasmic); 177–192 (Extracellular); 218–251 (Cytoplasmic); 275–280 (Extracellular); 304–334 (Cytoplasmic)
Lipid attachment sites
317–317: S-palmitoyl cysteine
317–317 (S-palmitoyl cysteine)
Source-annotated extracellular intervals
1–48104–113177–192275–280
1–48; 104–113; 177–192; 275–280

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
14848
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
142a03049ecc7dfb151aee5b9bb2806842e1c7fef7f46a18948bb6f2465199af
10411310
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
10118d561adc9448a6f5c7fd5c6d762f7102a04f79bde0dfb5f1c2ab86c692c2
17719216
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
9e62d5dfb8b4f4f1dfd1818161654b379b7433c7342cd84c5cf4e114284ca2e9
2752806
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
30570863e609d7baabda86a609552f3b0512f00cb74d64b73a0586e710ce3bdc
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

Download source snapshot

Open sequence source
Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
P47775

Download source snapshot (gzip)

subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
transmembrane
TRANSMEM 49..71; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:36593162"; TRANSMEM 78..103; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:36593162"; TRANSMEM 114..136; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:36593162"; TRANSMEM 154..176; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:36593162"; TRANSMEM 193..217; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:36593162"; TRANSMEM 252..274; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:36593162"; TRANSMEM 281..303; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:36593162"
topological_domain
TOPO_DOM 1..48; /note="Extracellular"; /evidence="ECO:0000269|PubMed:36593162"; TOPO_DOM 72..77; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:36593162"; TOPO_DOM 104..113; /note="Extracellular"; /evidence="ECO:0000269|PubMed:36593162"; TOPO_DOM 137..153; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:36593162"; TOPO_DOM 177..192; /note="Extracellular"; /evidence="ECO:0000269|PubMed:36593162"; TOPO_DOM 218..251; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:36593162"; TOPO_DOM 275..280; /note="Extracellular"; /evidence="ECO:0000269|PubMed:36593162"; TOPO_DOM 304..334; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:36593162"
signal_peptide
Not recorded
lipidation
LIPID 317; /note="S-palmitoyl cysteine"; /evidence="ECO:0000250"

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
G protein-coupled receptor 12
Protein location
Transmembrane protein
Canonical sequence
P47775 · 334 amino acids
Extracellular region
UniProt annotates extracellular residues 1–48, 104–113, 177–192, 275–280.

Expression in normal tissues

RNA specificity
Tissue enhanced
RNA distribution
Detected in some
RNA tissue-specific nTPM
brain: 11.6; retina: 7.8; skin 1: 5.1
Protein specificity
Not detected
Protein distribution
Not detected
Immunohistochemistry reliability
Uncertain
Tissue cell-type enrichment
Breast - Breast glandular cells (progenitors), Pituitary gland - Thyrotropes, Skin - Eccrine sweat gland cells, Testis - Late spermatids

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

GPR12 · ENSG00000132975 · P47775

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