GRIN2A

Glutamate receptor ionotropic, NMDA 2A. UniProt annotates extracellular residues 23–556, 647–814.

Sequence and protein regions

Explore the GRIN2A sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median GRIN2A RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples1.0

Other tumor types438 samples0.9

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000183454
UniProt accession: Q12879
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 1464
Sequence SHA-256: 1e865dd08ec23cfb4ba716c63359e383fb948aa26261eeb5a0f9d7462536db0f

View and select the full canonical sequence

Canonical amino-acid sequence

MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRSAKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNMNELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDSIRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNHKTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVTLPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPHSETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNPATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLLEGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIGRCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYSTPRVLNSCSNRRVYKKMPSIESDV

Sequence positions 1–1464

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–22

Membrane-spanning segments

557–576 (Helical); 626–646 (Helical); 815–835 (Helical)

Source-annotated domains

23–556 (Extracellular); 577–600 (Cytoplasmic); 616–625 (Cytoplasmic); 647–814 (Extracellular); 836–1464 (Cytoplasmic)

Source-annotated extracellular intervals

23–556; 647–814

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
23	556	534	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 cfb40bb1a3b12fbc61b5cfc65cf0f67a36082f34d094e6d8d9ce108ce6c29951 Amino-acid sequence for this intervalPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSAS
647	814	168	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 5193569f90d6a85152a2e2c373bd6b321a454e162226d26928e70c3efed8c079 Amino-acid sequence for this intervalANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDI

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q12879

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subcellular_location: SUBCELLULAR LOCATION: Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q00959}. Cell membrane {ECO:0000269|PubMed:23933820, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:27839871, ECO:0000269|PubMed:28095420, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:28242877, ECO:0000269|PubMed:38538865, ECO:0000269|PubMed:8768735}; Multi-pass membrane protein {ECO:0000269|PubMed:34186027}. Synapse {ECO:0000250|UniProtKB:P35436}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q00959}; Multi-pass membrane protein {ECO:0000269|PubMed:34186027}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P35436}. Note=Expression at the dendrite cell membrane and at synapses is regulated by SORCS2 and the retromer complex. {ECO:0000250|UniProtKB:P35436}.
transmembrane: TRANSMEM 557..576; /note="Helical"; /evidence="ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ"; TRANSMEM 626..646; /note="Helical"; /evidence="ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ"; TRANSMEM 815..835; /note="Helical"; /evidence="ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ"
topological_domain: TOPO_DOM 23..556; /note="Extracellular"; /evidence="ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ"; TOPO_DOM 577..600; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ"; TOPO_DOM 616..625; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ"; TOPO_DOM 647..814; /note="Extracellular"; /evidence="ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ"; TOPO_DOM 836..1464; /note="Cytoplasmic"; /evidence="ECO:0000269|PubMed:34186027, ECO:0007744|PDB:7EOQ"
signal_peptide: SIGNAL 1..22; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Glutamate receptor ionotropic, NMDA 2A
Protein location: Transmembrane protein
Canonical sequence: Q12879 · 1,464 amino acids
Extracellular region: UniProt annotates extracellular residues 23–556, 647–814.

Expression in normal tissues

RNA specificity: Tissue enriched
RNA distribution: Detected in some
RNA tissue-specific nTPM: brain: 15.1
Protein specificity: Tissue enriched
Protein distribution: Detected in single
Immunohistochemistry reliability: Enhanced
Immunofluorescence reliability: Uncertain
Protein tissue-specific intensity: cerebral cortex: 6,963,920.0
Tissue cell-type enrichment: Adipose subcutaneous - Smooth muscle cells, Heart muscle - Cardiomyocytes
Subcellular location: Endoplasmic reticulum

Human Protein Atlas: GRIN2A

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

GRIN2A · ENSG00000183454 · Q12879