GRPR

Gastrin-releasing peptide receptor. UniProt annotates extracellular residues 1–38, 97–114, 175–208, 286–298.

Sequence and protein regions

Explore the GRPR sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median GRPR RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples1.9

Other tumor types438 samples5.1

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000126010
UniProt accession: P30550
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 384
Sequence SHA-256: 65221c4df869b7962744a9424e56af2329253da769121e160384ea87f7d59624

View and select the full canonical sequence

Canonical amino-acid sequence

MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTSLKSTNPSVATFSLINGNICHERYV

Sequence positions 1–384

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Membrane-spanning segments

39–62 (Helical; Name=1); 77–96 (Helical; Name=2); 115–136 (Helical; Name=3); 153–174 (Helical; Name=4); 209–234 (Helical; Name=5); 265–285 (Helical; Name=6); 299–325 (Helical; Name=7)

Source-annotated domains

1–38 (Extracellular); 63–76 (Cytoplasmic); 97–114 (Extracellular); 137–152 (Cytoplasmic); 175–208 (Extracellular); 235–264 (Cytoplasmic); 286–298 (Extracellular); 326–384 (Cytoplasmic)

Lipid attachment sites

339–339 (S-palmitoyl cysteine)

Source-annotated extracellular intervals

1–38; 97–114; 175–208; 286–298

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
1	38	38	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 7d200fd7f3a02d8850f09c27a53d7e9db0b086d5c2511c91f3b55d84ca70e646 Amino-acid sequence for this intervalMALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPG
97	114	18	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 409bfcea0b64cd5c1557ed9701f2bd1fc2b33f100d4e35969e9cfe057a766a27 Amino-acid sequence for this intervalDASRYLADRWLFGRIGCK
175	208	34	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 b7ce146902a74b518d03201e9e49f49f542f6728d6fa35eea3fbd32f25b51494 Amino-acid sequence for this intervalEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPK
286	298	13	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 12476790a725b410334f2e618776c2625e605266519e7328844216026cad72f9 Amino-acid sequence for this intervalYRSYHYSEVDTSM

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: P30550

Download source snapshot (gzip)

subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1655761}; Multi-pass membrane protein {ECO:0000255}.
transmembrane: TRANSMEM 39..62; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 77..96; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 115..136; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 153..174; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 209..234; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 299..325; /note="Helical; Name=7"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 1..38; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 63..76; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 97..114; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 137..152; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 175..208; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 235..264; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 286..298; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 326..384; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: Not recorded
lipidation: LIPID 339; /note="S-palmitoyl cysteine"; /evidence="ECO:0000250"

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Gastrin-releasing peptide receptor
Protein location: Transmembrane protein
Canonical sequence: P30550 · 384 amino acids
Extracellular region: UniProt annotates extracellular residues 1–38, 97–114, 175–208, 286–298.

Expression in normal tissues

RNA specificity: Tissue enriched
RNA distribution: Detected in some
RNA tissue-specific nTPM: pancreas: 19.1
Protein specificity: Not detected
Protein distribution: Not detected
Immunofluorescence reliability: Supported
Subcellular location: Plasma membrane

Human Protein Atlas: GRPR

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

GRPR · ENSG00000126010 · P30550