Surface AtlasMucinous colon cancer

LGR6

Leucine-rich repeat-containing G protein-coupled receptor 6. UniProt annotates extracellular residues 25–567, 620–644, 709–727, 796–809.

Sequence and protein regions

Explore the LGR6 sequence, select annotated regions, and copy a request to continue in Codex.

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RNA expression in tumor samples

Median LGR6 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples235.4
Other tumor types438 samples357.8
Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID
T-ENSG00000133067
UniProt accession
Q9HBX8
Sequence state
available
Canonical sequence
Yes
Length in amino acids
967
Sequence SHA-256
3516f5207cb15271b20a091837c8200814b81e67de26a6fb9572dd4030f21631
View and select the full canonical sequence
Sequence positions 1–967

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide
1–24
1–24
Membrane-spanning segments
568–588: Helical; Name=1599–619: Helical; Name=2645–665: Helical; Name=3688–708: Helical; Name=4728–748: Helical; Name=5775–795: Helical; Name=6810–830: Helical; Name=7
568–588 (Helical; Name=1); 599–619 (Helical; Name=2); 645–665 (Helical; Name=3); 688–708 (Helical; Name=4); 728–748 (Helical; Name=5); 775–795 (Helical; Name=6); 810–830 (Helical; Name=7)
Source-annotated domains
25–567: Extracellular589–598: Cytoplasmic620–644: Extracellular666–687: Cytoplasmic709–727: Extracellular749–774: Cytoplasmic796–809: Extracellular831–967: Cytoplasmic
25–567 (Extracellular); 589–598 (Cytoplasmic); 620–644 (Extracellular); 666–687 (Cytoplasmic); 709–727 (Extracellular); 749–774 (Cytoplasmic); 796–809 (Extracellular); 831–967 (Cytoplasmic)
Source-annotated extracellular intervals
25–567620–644709–727796–809
25–567; 620–644; 709–727; 796–809

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
StartEndLengthSequence and source
25567543
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
b3f6b853bb82ce83d93426c8350970629426568ad62b735e02c740f7bd0a2704
62064425
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
b1e97d617d137d142ff587caa17c6c3a2068d79a6a75e8715fd717d90a6a0d82
70972719
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
d0a7669a14bf493901cd5c4794ec14c8069ce35e0b6292d0f8c488401101bd7a
79680914
Sequence and source
Basis
reviewed-uniprot-topological-domain
Evidence class
source-annotated-topology
Sequence SHA-256
4f66bc1cd0b250e16bfaf5b151c2d09ef7f73692f9107461c0514789e976105e
Sequence and topology sources
Source role
canonical-sequence
Source
alphafold-db-canonical-uniprot-field
Extracted field
uniprotSequence
Source row accession
Not recorded

Download source snapshot

Open sequence source
Source role
reviewed-topology
Source
UniProt reviewed human surface-field snapshot
Extracted field
Not recorded
Source row accession
Q9HBX8

Download source snapshot (gzip)

subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22615920}; Multi-pass membrane protein {ECO:0000269|PubMed:22615920}.
transmembrane
TRANSMEM 568..588; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 599..619; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 645..665; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 688..708; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 728..748; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 775..795; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 810..830; /note="Helical; Name=7"; /evidence="ECO:0000255"
topological_domain
TOPO_DOM 25..567; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 589..598; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 620..644; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 666..687; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 709..727; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 749..774; /note="Cytoplasmic"; /evidence="ECO:0000255"; TOPO_DOM 796..809; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 831..967; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide
SIGNAL 1..24; /evidence="ECO:0000255"
lipidation
Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein
Leucine-rich repeat-containing G protein-coupled receptor 6
Protein location
Transmembrane protein
Canonical sequence
Q9HBX8 · 967 amino acids
Extracellular region
UniProt annotates extracellular residues 25–567, 620–644, 709–727, 796–809.

Expression in normal tissues

RNA specificity
Tissue enhanced
RNA distribution
Detected in many
RNA tissue-specific nTPM
blood vessel: 66.9
Protein specificity
Not detected
Protein distribution
Not detected
Immunohistochemistry reliability
Approved
Immunofluorescence reliability
Approved
Tissue cell-type enrichment
Adipose subcutaneous - Smooth muscle cells, Adipose visceral - Smooth muscle cells, Kidney - Fibroblasts, Pituitary gland - Undifferentiated cells (Pituitary gland), Skeletal muscle - Smooth muscle cells, Spleen - Fibroblasts_1, Testis - Early spermatids
Subcellular location
Plasma membrane

Sources and downloads

UniProt protein recordTarget measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

LGR6 · ENSG00000133067 · Q9HBX8

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