LILRB1

Leukocyte immunoglobulin-like receptor subfamily B member 1. UniProt annotates extracellular residues 24–461.

Sequence and protein regions

Explore the LILRB1 sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median LILRB1 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples69.6

Other tumor types438 samples49.0

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000104972
UniProt accession: Q8NHL6
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 650
Sequence SHA-256: 4ec1b53535c88046381a722b24bf23a972bb0d628fb28d20fee160b38f130163

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Canonical amino-acid sequence

MTPILTVLICLGLSLGPRTHVQAGHLPKPTLWAEPGSVITQGSPVTLRCQGGQETQEYRLYREKKTALWITRIPQELVKKGQFPIPSITWEHAGRYRCYYGSDTAGRSESSDPLELVVTGAYIKPTLSAQPSPVVNSGGNVILQCDSQVAFDGFSLCKEGEDEHPQCLNSQPHARGSSRAIFSVGPVSPSRRWWYRCYAYDSNSPYEWSLPSDLLELLVLGVSKKPSLSVQPGPIVAPEETLTLQCGSDAGYNRFVLYKDGERDFLQLAGAQPQAGLSQANFTLGPVSRSYGGQYRCYGAHNLSSEWSAPSDPLDILIAGQFYDRVSLSVQPGPTVASGENVTLLCQSQGWMQTFLLTKEGAADDPWRLRSTYQSQKYQAEFPMGPVTSAHAGTYRCYGSQSSKPYLLTHPSDPLELVVSGPSGGPSSPTTGPTSTSGPEDQPLTPTGSDPQSGLGRHLGVVIGILVAVILLLLLLLLLFLILRHRRQGKHWTSTQRKADFQHPAGAVGPEPTDRGLQWRSSPAADAQEENLYAAVKHTQPEDGVEMDTRSPHDEDPQAVTYAEVKHSRPRREMASPPSPLSGEFLDTKDRQAEEDRQMDTEAAASEAPQDVTYAQLHSLTLRREATEPPPSQEGPSPAVPSIYATLAIH

Sequence positions 1–650

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–23

Membrane-spanning segments

462–482 (Helical)

Source-annotated domains

24–461 (Extracellular); 483–650 (Cytoplasmic)

Source-annotated extracellular intervals

24–461

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
24	461	438	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 fdce68e61be942d041572b3f4af18762d8e447cc306ba4135c343ed3ce6f5048 Amino-acid sequence for this intervalGHLPKPTLWAEPGSVITQGSPVTLRCQGGQETQEYRLYREKKTALWITRIPQELVKKGQFPIPSITWEHAGRYRCYYGSDTAGRSESSDPLELVVTGAYIKPTLSAQPSPVVNSGGNVILQCDSQVAFDGFSLCKEGEDEHPQCLNSQPHARGSSRAIFSVGPVSPSRRWWYRCYAYDSNSPYEWSLPSDLLELLVLGVSKKPSLSVQPGPIVAPEETLTLQCGSDAGYNRFVLYKDGERDFLQLAGAQPQAGLSQANFTLGPVSRSYGGQYRCYGAHNLSSEWSAPSDPLDILIAGQFYDRVSLSVQPGPTVASGENVTLLCQSQGWMQTFLLTKEGAADDPWRLRSTYQSQKYQAEFPMGPVTSAHAGTYRCYGSQSSKPYLLTHPSDPLELVVSGPSGGPSSPTTGPTSTSGPEDQPLTPTGSDPQSGLGRHLGV

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q8NHL6

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20448110, ECO:0000269|PubMed:24453251, ECO:0000269|PubMed:29262349, ECO:0000305|PubMed:19658091}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted {ECO:0000269|PubMed:19658091}.
transmembrane: TRANSMEM 462..482; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 24..461; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 483..650; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..23; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Leukocyte immunoglobulin-like receptor subfamily B member 1
Protein location: Transmembrane protein
Canonical sequence: Q8NHL6 · 650 amino acids
Extracellular region: UniProt annotates extracellular residues 24–461.

Expression in normal tissues

RNA specificity: Tissue enriched
RNA distribution: Detected in many
RNA tissue-specific nTPM: lymphoid tissue: 48.0
Tissue cell-type enrichment: Adipose subcutaneous - Macrophages, Adipose visceral - Macrophages, Adrenal gland - Macrophages, Liver - Kupffer cells, Prostate - T-cells

Human Protein Atlas: LILRB1

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

LILRB1 · ENSG00000104972 · Q8NHL6