LRRC15

Leucine-rich repeat-containing protein 15. UniProt annotates extracellular residues 22–538.

Sequence and protein regions

Explore the LRRC15 sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median LRRC15 RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples286.0

Other tumor types438 samples213.7

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000172061
UniProt accession: Q8TF66
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 581
Sequence SHA-256: ce37201f3a38d7fa353e7de5dbd53622fc5d0b4eef105502d93abca59834f0f7

View and select the full canonical sequence

Canonical amino-acid sequence

MPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPEVPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLAIAAIVIGIVALACSLAACVGCCCCKKRSQAVLMQMKAPNEC

Sequence positions 1–581

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–21

Membrane-spanning segments

539–559 (Helical)

Source-annotated domains

22–538 (Extracellular); 560–581 (Cytoplasmic)

Source-annotated extracellular intervals

22–538

UniProt annotates the following extracellular intervals.

One-based positions include both interval endpoints.
Start	End	Length	Sequence and source
22	538	517	Sequence and source Basis reviewed-uniprot-topological-domain Evidence class source-annotated-topology Sequence SHA-256 7e499dc55b3380f73adf51a27fc4214f7d39348289f5b08402b7df09e7767ec4 Amino-acid sequence for this intervalYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPEVPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSG

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q8TF66

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subcellular_location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:36228039, ECO:0000269|PubMed:36735681, ECO:0000269|PubMed:36757924}; Single-pass type I membrane protein {ECO:0000255}.
transmembrane: TRANSMEM 539..559; /note="Helical"; /evidence="ECO:0000255"
topological_domain: TOPO_DOM 22..538; /note="Extracellular"; /evidence="ECO:0000255"; TOPO_DOM 560..581; /note="Cytoplasmic"; /evidence="ECO:0000255"
signal_peptide: SIGNAL 1..21; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Leucine-rich repeat-containing protein 15
Protein location: Transmembrane protein
Canonical sequence: Q8TF66 · 581 amino acids
Extracellular region: UniProt annotates extracellular residues 22–538.

Expression in normal tissues

RNA specificity: Tissue enhanced
RNA distribution: Detected in many
RNA tissue-specific nTPM: lymphoid tissue: 4.6; skin 1: 6.7
Protein specificity: Tissue enriched
Protein distribution: Detected in some
Immunohistochemistry reliability: Uncertain
Immunofluorescence reliability: Approved
Protein tissue-specific intensity: skin: 2,272,492.7
Tissue cell-type enrichment: Adipose subcutaneous - Adipose progenitor cells, Minor Salivary Gland - Fibroblasts, Skeletal muscle - Fibroblasts, Skin - Hair cortex cells, Skin - Inner root sheath cells, Skin - Outer root sheath cells, Thyroid gland - Fibroblasts
Subcellular location: Vesicles

Human Protein Atlas: LRRC15

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

LRRC15 · ENSG00000172061 · Q8TF66