LRRC4C

Leucine-rich repeat-containing protein 4C. The canonical sequence contains 640 amino acids.

Sequence and protein regions

Explore the LRRC4C sequence, select annotated regions, and copy a request to continue in Codex.

RNA expression in tumor samples

Median LRRC4C RNA expression by tumor type, measured in RSEM units. The study selected these samples using microsatellite-stability score thresholds.

Mucinous tumors37 samples1.7

Other tumor types438 samples1.7

Compare the sample groups · cBioPortal measurements (JSON)

Sequence & binding sites

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Sequence annotations and source records

Canonical sequence and topology

Target ID: T-ENSG00000148948
UniProt accession: Q9HCJ2
Sequence state: available
Canonical sequence: Yes
Length in amino acids: 640
Sequence SHA-256: aa2275ada024fd3f4a739403929e6b516734aa126ba14a85fc845765b7852b49

View and select the full canonical sequence

Canonical amino-acid sequence

MLNKMTLHPQQIMIGPRFNRALFDPLLVVLLALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTPVVDWETTNVTTSLTPQSTRSTEKTFTIPVTDINSGIPGIDEVMKTTKIIIGCFVAITLMAAVMLVIFYKMRKQHHRQNHHAPTRTVEIINVDDEITGDTPMESHLPMPAIEHEHLNHYNSYKSPFNHTTTVNTINSIHSSVHEPLLIRMNSKDNVQETQI

Sequence positions 1–640

Gray shows the full canonical sequence. Colored spans mark the listed intervals.

Signal peptide

1–44

Membrane-spanning segments

528–548 (Helical)

This collection has no explicit extracellular interval for this protein.

Sequence and topology sources

Source role: canonical-sequence
Source: alphafold-db-canonical-uniprot-field
Extracted field: uniprotSequence
Source row accession: Not recorded

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Open sequence source

Source role: reviewed-topology
Source: UniProt reviewed human surface-field snapshot
Extracted field: Not recorded
Source row accession: Q9HCJ2

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subcellular_location: SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:14595443, ECO:0000269|PubMed:21946559}; Single-pass type I membrane protein {ECO:0000269|PubMed:14595443, ECO:0000269|PubMed:21946559}.
transmembrane: TRANSMEM 528..548; /note="Helical"; /evidence="ECO:0000255"
topological_domain: Not recorded
signal_peptide: SIGNAL 1..44; /evidence="ECO:0000255"
lipidation: Not recorded

Download all canonical target sequences (FASTA)

Protein identity and location

Protein: Leucine-rich repeat-containing protein 4C
Protein location: Transmembrane protein
Canonical sequence: Q9HCJ2 · 640 amino acids

Expression in normal tissues

RNA specificity: Group enriched
RNA distribution: Detected in many
RNA tissue-specific nTPM: brain: 19.4; retina: 15.8
Protein specificity: Tissue enriched
Protein distribution: Detected in single
Immunohistochemistry reliability: Supported
Immunofluorescence reliability: Approved
Protein tissue-specific intensity: cerebral cortex: 146,898.3
Tissue cell-type enrichment: Colon - Enteric glia cells, Liver - Hepatic stellate cells, Prostate - Fibroblasts, Skeletal muscle - Fibroblasts
Subcellular location: Cytosol

Human Protein Atlas: LRRC4C

Sources and downloads

UniProt protein record Target measurements (JSON)Sequence annotations (JSON)Target sequences (FASTA)

LRRC4C · ENSG00000148948 · Q9HCJ2